Endoscopy 2025; 57(S 02): S442-S443
DOI: 10.1055/s-0045-1806135
Abstracts | ESGE Days 2025
ePosters

Correlation of NF-kappa B and beta catenin expression for enhancing monitoring accuracy and complications risk in patients with IBD

A Juniku Shkololli
1   University of Prishtina, University Clinical Center of Kosovo, Pristina, Kosovo
,
V Hamza
2   University Clinical Center of Kosovo, Prishtina, Albania
› Author Affiliations
 

Aims Inflammatory bowel disease (IBD) is a chronic pathology, whose most important complication is colitis associated cancer (CAC). The link between inflammation and cancer has been excessively investigated. In this context, the correlation between NF-kappa B and beta-catenin has been studied by numerous authors, but the results were contradictory. Our study will contribute in clarifying this issue, moreover by performing IHC analysis in human colorectal tissues [1] [2] [3] [4] [5] [6] [7] [8] [9].

Methods In this cross-sectional study, tissue samples were collected from patients who underwent colonoscopy for confirmation/evaluation of IBD, including its both forms: Crohn’s disease and ulcerative colitis. Immunohistochemostry (IHC) using monoclonal antibodies was performed for NF kappa B and beta catenin. Staining patterns were evaluated, by including analysis of both expression and localization.

Results NF kappaB and beta catenin were upregulated in colorectal tissues of patients suffering from IBD, compared with controls. We found a significant positive correlation (p=0.037) of immunohistochemical expression of these markers, both involved in malignant alteration of inflamed colon cells. Nuclear beta catenin expression was found in 11.1% of patients with IBD, while nuclear NF kappa B expression was 47.2%. Interestingly, overexpresson of beta catenin was more remarkable in colon cells of patients with Crohn’s disease.

Conclusions Our findings indicate that NF kappa B and beta catenin could serve as diagnostic and prognostic markers in the development of CAC in patients with IBD. This study contributes in establishing most useful molecular markers, which can predict the risk for mucosal dysplasia.



Publication History

Article published online:
27 March 2025

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