Triglyceride glucose index (Tyg index) and colorectal adenoma risk based on health screening data

Aims Insulin resistance is associated with the risk of colorectal adenoma. Insulin resistance has been constantly associated with high triglyceride (TG) level. TyG index is a useful indicator of insulin resistance calculated by TG and plasma glucose levels. We examined the association of Tyg index and various other variables with colorectal adenoma risk in a health screening setting.

Methods This study was performed on 7251 subjects who underwent colonoscopy at university hospitals in Daejeon and Chungcheong province from November 2019 to June 2022. Logistic regression model was used to investigate the relationship between the risk of colorectal adenoma and variables including TyG index [1] [2] [3] [4] [5].

Results The mean of age, BMI, fasting glucose level, HbA1C, fasting triglyceride level, and TyG index were all significantly higher in the group with colorectal adenomas (p<0.001, all). Logistic regression analysis showed that obesity (BMI>25) [adjusted odds ratio (OR), 1.365; 95% Confidence interval (CI), 1.208–1.541; p<0.001], DM (HbA1C≥6.5%) [adjusted OR, 1.375; 95% CI, 1.175–1.609; p<0.001], metabolic syndrome [adjusted OR, 1.441; 95% CI, 1.294–1.603; p<0.001] and TyG index [adjusted OR, 1.351; 95% CI, 1.241–1.471; p<0.001] were positively associated with colorectal adenomas. There was no significant association between high-LDL level (> 130 mg/dl) and the risk of colorectal adenomas [adjusted OR, 1.053; 95% CI, 0.948–1.189; p=0.301].

Conclusions Lipid profile is related to the risk of developing colorectal adenomas. LDL level, which is considered clinically important, did not have a correlation, but low-HDL level and high-TG level had significant correlation. TyG index can be used to predict the risk of colorectal adenomas. Therefore, TyG index can be a simple and useful indicator for identifying people who are recommended for screening colonoscopy.

Publikationsverlauf

Artikel online veröffentlicht:
27. März 2025

• References

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