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CC BY-NC-ND 4.0 · Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery 2025; 44(02): e77-e87
DOI: 10.1055/s-0045-1809629
Original Article

Minimally Invasive Punch Biopsy for Malignant Brain Tumor

Biópsia por punção minimamente invasiva para tumores cerebrais malignos
Jamerson Ademir Cantarelli de Carvalho
1   Department of Medicine, Federal University of Sergipe, Aracaju, SE, Brazil
2   Department of Medicine, Hospital de Cirurgia, Aracaju, SE, Brazil
,
Letícia Adrielle dos Santos
1   Department of Medicine, Federal University of Sergipe, Aracaju, SE, Brazil
,
Arthur Maynart Pereira de Oliveira
1   Department of Medicine, Federal University of Sergipe, Aracaju, SE, Brazil
2   Department of Medicine, Hospital de Cirurgia, Aracaju, SE, Brazil
,
Gabriel Lucas Souza Abreu
1   Department of Medicine, Federal University of Sergipe, Aracaju, SE, Brazil
,
Ivison Xavier Duarte
2   Department of Medicine, Hospital de Cirurgia, Aracaju, SE, Brazil
,
Isaac Lohan Matos Vieira 
3   Department of Medicine, Tiradentes University, Aracaju, SE, Brazil
,
Bruno Fernandes de Oliveira Santos 
4   Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, SE, Brazil
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Abstract

Objective

To describe an innovative minimally invasive technique for brain lesion biopsy with low cost, high precision, and reduced surgical risk in addition to providing sufficient material for pathological analysis.

Methods

This is a consecutive series of cases of patients with intracranial expansive lesions with low resection possibility and high surgical risk. They were admitted to the Sergipe Emergency Hospital from March 2020 to November 2020. The approach point was determined using the NeuroKeypoint app.

Results

The same procedure was performed on five patients with sedation and local anesthesia. The small treatment required reduced surgical time. All five patients had a diagnosis after collecting performed with the device and did not experience any complications associated with the method. All patients were discharged the following day, maintaining their preoperative neurological condition. Of the five patients who underwent surgery, all had confirmatory results of malignant brain tumors, with 100% accuracy, confirming the diagnosis and enabling oncological therapeutic follow-up. During the 30-day follow-up, three patients received adjuvant therapy, while two died from systemic oncological complications.

Conclusion

The presented method is feasible, safe, and has acceptable diagnostic accuracy, offering an alternative for diagnosing histological malignant brain tumors through minimally invasive biopsy.

Resumo

Objetivo

Descrever uma técnica inovadora e minimamente invasiva para biópsia de lesão cerebral, com baixo custo, alta precisão, risco cirúrgico reduzido, além de fornecer material suficiente para análise anatomopatológica.

Métodos

Trata-se de uma série consecutiva de casos de pacientes com lesões expansivas intracranianas com baixa possibilidade de ressecção e alto risco cirúrgico. Eles deram entrada no Hospital de Emergência de Sergipe de março de 2020 a novembro de 2020. O ponto de abordagem foi determinado usando o aplicativo NeuroKeypoint.

Resultados

O mesmo procedimento foi realizado em cinco pacientes com sedação e anestesia local. A pequena trepanação exigiu redução do tempo cirúrgico. Todos os cinco pacientes apresentaram resposta positiva ao procedimento e não apresentaram complicações associadas ao método. Todos os pacientes receberam alta hospitalar no dia seguinte, mantendo o quadro neurológico pré-operatório. Dos cinco pacientes operados, todos apresentaram resultados confirmatórios de tumores cerebrais malignos, com 100% de acurácia, confirmando o diagnóstico e possibilitando o acompanhamento terapêutico oncológico. Durante os 30 dias de seguimento, três pacientes receberam terapia adjuvante, enquanto dois morreram por complicações oncológicas sistêmicas.

Conclusão

O método apresentado é factível, seguro e de acurácia diagnóstica aceitável, oferecendo uma alternativa para o diagnóstico histológico de tumores cerebrais malignos por meio de biópsia minimamente invasiva.

Keywords

brain neoplasms - biopsy - low-cost technology - culturally appropriate technology

Palavras-chave

neoplasias encefálicas - biópsia - tecnologia de baixo custo - tecnologia culturalmente apropriada


Publication History

Received: 15 August 2023

Accepted: 20 March 2025

Article published online:
16 July 2025

© 2025. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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