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CC BY 4.0 · Journal of Coloproctology 2025; 45(02): s00451809671
DOI: 10.1055/s-0045-1809671
Original Article

Colorectal Cancer Mortality Across the American Continent: Temporal Trends

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Funding The author(s) received no financial support for the research.
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Abstract

Introduction

Colorectal cancer (CRC) is a major global health concern and a leading cause of cancer-related mortality. Understanding temporal trends in CRC mortality is crucial for guiding public health policies and resource allocation.

Objective

To evaluate the temporal trends of CRC mortality rates across the American continent.

Materials and Methods

This retrospective, population-based study used data from the Pan American Health Organization for its development. Age-adjusted mortality rates per 100,000 individuals were collected for the period 2000–2019 and stratified by country and sex. Joinpoint regression analysis was conducted to estimate the annual percentage change (APC) and assess temporal trends.

Results

CRC mortality trends varied across regions and sexes. In South and Central America, mortality rates increased, particularly in the early 2000s, whereas North America experienced a general decline. Gender-specific trends showed significant increases in South and Central American women, while men exhibited rising trends except in North America, where rates steadily declined.

Conclusions

The study identified distinct trends in CRC mortality across the Americas, with increasing rates in some countries and declines in others. Socioeconomic factors, healthcare access, and sex-based differences appear to contribute to these variations. These findings underscore the need for targeted public health strategies to reduce colorectal cancer burden and address disparities in early detection and treatment.

Keywords

America - mortality - colorectal cancer - sex

Declaration of the Use of Artificial Intelligence

None.




Publikationsverlauf

Eingereicht: 06. März 2025

Angenommen: 22. Mai 2025

Artikel online veröffentlicht:
30. Juni 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Lucas Casagrande Passoni Lopes. Colorectal Cancer Mortality Across the American Continent: Temporal Trends. Journal of Coloproctology 2025; 45: s00451809671.
DOI: 10.1055/s-0045-1809671