RSS-Feed abonnieren

DOI: 10.1055/s-0045-1811251
A Case Report: Liver and Splenic Abscess Caused by Burkholderia pseudomallei
Authors
Funding None.

Abstract
Melioidosis is an emerging infectious disease in India which presents with febrile illness ranging from septicemia to localized abscess formation. We present a case of a 61-year-old male who presented with fever of almost 2 months' duration, persistent pneumonia, and liver and splenic abscesses. Aspiration of hepatic fluid collection and subsequent culture yielded Gram-negative bacilli, which was identified as Burkholderia pseudomallei. He was treated successfully with surgical drainage of abscess and prolonged course of intravenous and oral antibiotics. So, in cases of pyogenic liver abscess not responding to conventional antibiotics, B. pseudomallei should always be thought as a possible cause, which can be identified by its characteristic appearance on culture and microscopy and accurately identified by automated identification systems.
Ethical Statement
None.
Authors' Contributions
All authors contributed equally to the article.
Data Availability Statement
There is no data associated with this work.
Publikationsverlauf
Eingereicht: 27. Februar 2025
Angenommen: 27. Juli 2025
Artikel online veröffentlicht:
06. Oktober 2025
© 2025. Gastrointestinal Infection Society of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Chaowagul W, White NJ, Dance DA. et al. Melioidosis: a major cause of community-acquired septicemia in northeastern Thailand. J Infect Dis 1989; 159 (05) 890-899
- 2 Currie BJ, Dance DAB, Cheng AC. The global distribution of Burkholderia pseudomallei and melioidosis: an update. Trans R Soc Trop Med Hyg 2008; 102 (Suppl. 01) S1-S4
- 3 Ramphal R. Chapter 152. Infections due to pseudomonas species and related organisms. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J. eds. Harrison's Principles of Internal Medicine. 18th ed. New York: McGraw-Hill; 2012
- 4 White NJ. Melioidosis. Lancet 2003; 361 (9370) 1715-1722
- 5 Pal P, Ray S, Moulick A, Dey S, Jana A, Banerjee K. Liver abscess caused by Burkholderia pseudomallei in a young man: a case report and review of literature. World J Clin Cases 2014; 2 (10) 604-607
- 6 Vidyalakshmi K, Shrikala B, Bharathi B, Suchitra U. Melioidosis: an under-diagnosed entity in western coastal India: a clinico-microbiological analysis. Indian J Med Microbiol 2007; 25 (03) 245-248
- 7 Saravu K, Mukhopadhyay C, Vishwanath S. et al. Melioidosis in southern India: epidemiological and clinical profile. Southeast Asian J Trop Med Public Health 2010; 41 (02) 401-409
- 8 Easow JM, Bhosale NK, Pramodhini S, Priyadarshini R. Case series of melioidosis in a tertiary health care centre in Puducherry, India. J Pure Appl Microbiol 2024; 18 (01) 185-192
- 9 Loveleena CR, Chaudhry R, Dhawan B. Melioidosis; the remarkable imitator: recent perspectives. J Assoc Physicians India 2004; 52: 417-420
- 10 Cheng AC, Currie BJ. Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev 2005; 18 (02) 383-416
- 11 Mukhopadhya A, Balaji V, Jesudason MV, Amte A, Jeyamani R, Kurian G. Isolated liver abscesses in melioidosis. Indian J Med Microbiol 2007; 25 (02) 150-151
- 12 Raj S, Sistla S, Sadanandan DM, Kadhiravan T, Rameesh BMS, Amalnath D. Clinical profile and predictors of mortality among patients with melioidosis. J Glob Infect Dis 2023; 15 (02) 72-78
- 13 Koshy M. Melioidosis: an emerging infection in India. Curr Med Issues 2020; 18: 94-97
- 14 Suputtamongkol Y, Chaowagul W, Chetchotisakd P. et al. Risk factors for melioidosis and bacteremic melioidosis. Clin Infect Dis 1999; 29 (02) 408-413
- 15 Iyer RN, Jangam RR, Nara BK, Kondeti KA. Multiple hepatic and splenic abscesses due to Burkholderia pseudomallei. Indian J Med Microbiol 2021; 39 (02) 249-251
- 16 Apisarnthanarak A, Apisarnthanarak P, Mundy LM. Computed tomography characteristics of Burkholderia pseudomallei liver abscess. Clin Infect Dis 2006; 42 (07) 989-993
- 17 Dance D. Treatment and prophylaxis of melioidosis. Int J Antimicrob Agents 2014; 43 (04) 310-318
- 18 Chetchotisakd P, Porramatikul S, Mootsikapun P, Anunnatsiri S, Thinkhamrop B. Randomized, double-blind, controlled study of cefoperazone-sulbactam plus cotrimoxazole versus ceftazidime plus cotrimoxazole for the treatment of severe melioidosis. Clin Infect Dis 2001; 33 (01) 29-34
- 19 Chetchotisakd P, Chierakul W, Chaowagul W. et al. Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial. Lancet 2014; 383 (9919) 807-814