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Synlett 1992; 1992(7): 553-555
DOI: 10.1055/s-1992-21411
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A Useful Method for the Synthesis of β-2′,3′-Dideoxynucleosides via a Thioglycoside

Keiko Sujino* , Hideyuki Sugimura
  • *The Noguchi Institute, 1-8-1, Kaga, Itabashi-ku, Tokyo 173, Japan
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Publikationsdatum:
08. März 2002 (online)

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A series of the protected β-2′,3′-dideoxypyrimidine nucleosides are synthesized stereoselectively by the coupling of phenyl 5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-1-thio-D-glycero-pentofuranoside with silyl derivatives of nucleoside bases in the presence of N-bromosuccinimide at -78 °C.