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Synlett 1994; 1994(2): 105-106
DOI: 10.1055/s-1994-22754
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Stereoselective Synthesis of (2S,4R)-2-Amino-4-hydroxyadipic Acid, the Characteristic Amino Acid of Theonellamide F

Keisuke Tohdo* , Yasumasa Hamada, Takayuki Shioiri
  • *Faculty of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, Nagoya 467, JAPAN
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Publikationsdatum:
22. März 2002 (online)

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(2S,4R)-2-Amino-4-hydroxyadipic acid (2), a constituent of theonellamide F (1) from a marine sponge, has been efficiently synthesized as its protected form 9a by asymmetric reduction of the ß-keto ester 6 derived from the protected aspartic acid derivative 5.