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Synlett 1994; 1994(2): 127-129
DOI: 10.1055/s-1994-22765
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A Novel Enzymatic Approach to the Synthesis of Chiral Sulfoxides: Enzymatic Hydrolysis of Prochiral Sulfinyldicarboxylates

Marian Mikołajczyk* , Piotr Kiełbasiński, Remigiusz Żurawiński, Michał W. Wieczorek, Jarosław Błaszczyk
  • *Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Department of Organic Sulfur Compounds, 90-363 Łódź Sienkiewicza 112, Poland
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Publication Date:
22 March 2002 (online)

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Methoxycarbonylmethyl carboxymethyl sulfoxide 3 and 2-acetoxyethyl 2-hydroxyethyl sulfoxide 4 have been obtained in high enantiomeric purity by the enzyme-mediated hydrolysis of the corresponding prochiral sulfinyldicarboxylates 1 and 2. The R configuration has been assigned to the enantiomerically pure (-)-3, [α]D 20 -20, by X-ray analysis.

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