A Direct Synthesis of Pharmacologically Active ortho-Substituted  Biaryls: A Combined Directed Metalation-Palladium Catalyzed Cross Coupling Approach Using  Aryl Oxazolines or Benzamides

K. Koch; R. J. Chambers; M. S. Biggers

doi:10.1055/s-1994-22849

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Synlett 1994; 1994(5): 347-348
DOI: 10.1055/s-1994-22849

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A Direct Synthesis of Pharmacologically Active ortho-Substituted Biaryls: A Combined Directed Metalation-Palladium Catalyzed Cross Coupling Approach Using Aryl Oxazolines or Benzamides

K. Koch^* , R. J. Chambers, M. S. Biggers

^*Central Research Division, Pfizer Inc. Groton, CT 06340 USA

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Publication Date:
22 March 2002 (online)

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A general combined directed metalation-transmetalation-cross coupling methodology for the regiospecific preparation of biologically active ortho biaryls is described.

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