Download PDF
Synlett 1994; 1994(6): 433-434
DOI: 10.1055/s-1994-22878
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Short Synthesis of (±)-Clavizepine

R. Vázquez* , M. C. de la Fuente, L. Castedo, D. Domínguez
  • *Departamento de Química Orgánica, Facultad de Química, Universidad de Santiago y Sección de Alcaloides del C.S.I.C. 15706 Santiago de Compostela, Spain
Further Information

Publication History

Publication Date:
18 September 2002 (online)

 PDF Download  Permissions and Reprints All articles of this category
Preview

A new synthesis of (±)-clavizepine is described which is based on the anionic cyclization of the bromo ester 5 to give the xanthene 9-carboxylate 6, followed by construction of the azepine ring by intramolecular aromatic substitution of the amido acetal 9.