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Synlett 1996; 1996(1): 69-71
DOI: 10.1055/s-1996-5320
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A Mild and Efficient Method for the Cleavage of tert-Butyldimethylsilyl and Tetrahydropyranyl Ethers by Ceric Ammonium Nitrate in Methanol

Arpita DattaGupta, Ramsharan Singh, Vinod K. Singh*
  • *Department of Chemistry, Indian Institute of Technology, Kanpur-208016, India
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Publication History

Publication Date:
31 December 2000 (online)

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A variety of tert-butyldimethylsilyl (TBDMS) and tetrahydropyranyl (TFP) ethers were cleaved with ceric ammonium nitrate in methanol at 0 °C in short time. It has been shown that the reaction is chemoselective in a few cases. The primary TBDMS ethers have been cleaved selectively in the presence of THP ether and ketal.

Deprotection - TBDMS ether - THP ether - CAN

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