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Synlett 1996; 1996(2): 143-144
DOI: 10.1055/s-1996-5341
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An Efficient Stereocontrolled Synthesis of (R)-2-Carboxy-4-(3-phosphonopropyl)piperazine [(R)-CPP]

Massimo Falorni* , Giampaolo Giacomelli
  • *Dipartimento di Chimica, Università di Sassari, via Vienna 2, I-07100 Sassari, Italy
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Publication History

Publication Date:
31 December 2000 (online)

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The amino acid (R)-CPP (1), a selective antagonist of the NMDA receptor, is prepared directly in enantiopure form starting from L-serine and sarcosine.

Unnatural α-amino acids - chiral piperazines - CPP - NMDA antagonists

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