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Synlett 1997; 1997(6): 659-660
DOI: 10.1055/s-1997-3252
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Addition of Organolithiums to the (R)-O-(1-Phenylbutyl)hydroxylamine (ROPHy) Oxime of Cinnamaldehyde. Asymmetric Synthesis of α-Aminoacids

Christopher J. Moody1 , Andrew P. Lightfoot2 , Peter T. Gallagher3
  • 1Department of Chemistry, Loughborough University, Loughborough LE11 3TU, UK, Phone: 01392 263429; Fax: 01392 263434; e-mail: C.J.Moody@exeter.ac.uk
  • 2Department of Chemistry, Loughborough University, Loughborough LE11 3TU, UK
  • 3Lilly Research Centre Limited, Erl Wood Manor, Sunninghill Road, Windlesham GU20 6PH, UK
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Publication Date:
31 December 2000 (online)

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A new asymmetric synthesis of α-aminoacids is described in which the key step is the diastereoselective addition of organolithium reagents to (R)-O-(1-phenylbutyl) cinnamaldoxime.

oxime ether - diastereoselective addition - hydroxylamine - aminoacid