The Catalytic Pauson-Khand Reaction Promoted by A Small Amount of 1,2-Dimethoxyethane or Water

Takumichi Sugihara; Masahiko Yamaguchi

doi:10.1055/s-1998-1991

Synlett 1998; 1998(12): 1384-1386
DOI: 10.1055/s-1998-1991

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The Catalytic Pauson-Khand Reaction Promoted by A Small Amount of 1,2-Dimethoxyethane or Water

Takumichi Sugihara^* , Masahiko Yamaguchi

^*Faculty of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8514, Japan; E-mail: taku@ph.bunri-u.ac.jp

Abstract

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Various "hard" Lewis bases having less nucleophilic nature promoted the catalytic Pauson-Khand reaction. Among those Lewis bases, 1,2-dimethoxyethane seems to be the most promising promoter and a small amount of water, which is the cheapest reagent, also effectively promoted the cyclization.

alkyne - catalyst - carbonyl complexes - cobalt - cyclization

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