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Synlett 1999; 1999(12): 1923-1924
DOI: 10.1055/s-1999-2978
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A Convenient Method for the N-Acylation and Esterification of Hindered Amino Acids: Synthesis of Ultra Short Acting Opioid Agonist, Remifentanil

Mark J. Coleman* , Michael D. Goodyear, David W. S. Latham, Andrew J. Whitehead
  • *Chemical Development Division, Glaxo Wellcome Research and Development, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
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Publication Date:
31 December 1999 (online)

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A general method has been devised for the one step preparation of N-acylamino acid esters of type 7 from the corresponding α-amino acids in high yield under mild conditions and a probable mechanism is proposed.

acylation - esterification - amino acids