PDF herunterladen
Synlett 2000; 2000(1): 137-139
DOI: 10.1055/s-2000-6462
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

The Synthesis of N-(Pyridylamino)tetrahydroisoquinolines and Benzazepines via The Pictet-Spengler Cyclization

Gregory H. Merriman* , David M. Fink, Brian S. Freed, Barbara E. Kurys, Shelly Pavlek, Jennifer Varriano, Erich F. Paulus
  • *Medicinal Chemistry Department, Hoechst Marion Roussel Pharmaceuticals, Bridgewater, New Jersey 08807-0800; Fax (908)231-4774; E-mail: gregory.merriman@hmrag.com
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

 als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik
Preview

A series of N-(pyridylamino)-tetrahydroisoquinolines and -benzazepines have been prepared using the Pictet-Spengler cyclization of an unprotected arylhydrazine as the key step.

Pictet-Spengler - tetrahydroisoquinolines - benzazepines - tetrazines - chloromethyl methyl ether