Download PDF
Synlett 2000; 2000(7): 1070-1072
DOI: 10.1055/s-2000-6655
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

First Synthesis and Determination of the Absolute Configuration of the Butenolide Fugomycin

Manfred Braun* , Jaykumar Rahematpura, Corinna Bühne, Thiomothy C. Paulitz
  • *Institut für Organische und Makromolekulare Chemie, Universität Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany; Fax + 211 81 13085; E-mail: braunm@uni-duesseldorf.de
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

The novel antifungal butenolide fugomycin (S)-1 was synthesized starting from the enantiomerically pure building block (S)-2. Its geminal dibromo substitution pattern permits gradual carbon-carbon bond formations in a stereoselective manner. The comparison of the CD spectra of natural and synthetic material permits the assignment of the absolute configuration to fugomycin.

chirality - lactones - lithiation - natural products - palladium

      >