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Synlett 2000; 2000(6): 0902-0904
DOI: 10.1055/s-2000-6717
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Preparation of α-Chloroketones by the Chloroacetate Claisen Reaction

Xuebao Wang* , John K. Thottathil, Richard P. Polniaszek
  • *Department of Process Research, Bristol-Myers Squibb, New Brunswick, NJ 08903-0191, USA
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Publikationsdatum:
31. Dezember 2000 (online)

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Claisen condensation of the dianion of chloroacetic acid with N-BOC α-amino acid methyl esters provides the corresponding α-chloroketones in high yield and enantiomeric excess.

amino acid - condensation - chloroketone