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Synlett 2001; 2001(3): 0341-0344
DOI: 10.1055/s-2001-11391
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A New Strategy for the Solid-Phase Synthesis of Glycoconjugate Biomolecules

Giovanni Di Fabio* , Antonia De Capua, Lorenzo De Napoli, Daniela Montesarchio, Gennaro Piccialli, Filomena Rossi, Ettore Benedetti
  • *Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli “Federico II”, Complesso Universitario di Monte S. Angelo, via Cinthia 4, 80126 Napoli, Italy; Fax + 39(0 81)67 43 93; E-mail: denapoli@cds.unina.it
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Publikationsdatum:
31. Dezember 2001 (online)

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A simple and efficient bidirectional solid-phase synthesis, based on the use of a Tentagel solid support, functionalized with a suitably protected 2-amino sugar residue, is proposed for the preparation of a variety of glycoconjugates, including glycopeptides and nucleo-glycopeptides.

conjugation - glycosylation - glycopeptides - oligonucleotides - solid-phase synthesis