Background and Study Aims: Percutaneous interstitial thermal ablation therapy effectively treats hepatocellular
carcinoma (HCC) that can be visualized on percutaneous ultrasonography. However, when
the tumor is located just under the top of the diaphragm, visualization can be difficult
with conventional ultrasonographic examination. There are also problems concerning
complete tumor ablation. We performed thoracoscopic thermal ablation therapy for HCC
located just beneath the diaphragm in nine patients with advanced liver cirrhosis.
Patients and Methods: Eight patients underwent thoracoscopic microwave coagulation therapy, and one patient
underwent thoracoscopic radiofrequency ablation therapy.
Results: Despite the poor hepatic reserve, postoperative recovery after thoracoscopic thermal
ablation therapy was rapid in all patients, without deterioration of hepatic function.
Conclusions: This preliminary study suggests that the new technique of thoracoscopic thermal ablation
therapy is a less invasive optional therapy for HCC located in segments VII or VIII
in cirrhotic patients.
References
- 1
Farmer D G, Rosove M H, Shaked A, et al.
Current treatment modalities for hepatocellular carcinoma.
Ann Surg.
1994;
219
236-247
- 2
lkeda K, Saitoh S, Tsubota A, et al.
Risk factors for tumor recurrence and prognosis after curative resection of hepatocellular
carcinoma.
Cancer.
1993;
71
19-25
- 3
Lee M J, Mueller P R, Dawson S L, et al.
Percutaneous ethanol injection for the treatment of hepatic tumors: indications, mechanism
of action, technique, and efficacy.
AJR Am J Roentgenol.
1995;
164
215-220
- 4
Shiina S, Tagawa K, Niwa Y, et al.
Percutaneous ethanol injection therapy for hepatocellular carcinoma; results in 146
patients.
AJR Am J Roentgenol.
1993;
160
1023-1028
- 5
Hamazoe R, Hirooka Y, Ohtani S, et al.
Intraoperative microwave coagulation as treatment for patients with unresectable hepatocellular
carcinoma.
Cancer.
1995;
75
794-800
- 6
Sato M, Watanabe Y, Ueda S, et al.
Microwave coagulation therapy for hepatocellular carcinoma.
Gastroenterology.
1996;
110
1507-1514
- 7
Allgaier H P, Deibert P, Zuber I, et al.
Percutaneous radiofrequency interstitial ablation of small hepatocellular carcinoma.
Lancet.
1999;
353
1676- 1677
- 8
Seki T, Wakabayashi M, Nakagawa T, et al.
Ultrasonically guided percutaneous microwave coagulation therapy for small hepatocellular
carcinoma.
Cancer.
1994;
74
817-825
- 9
Murakami R, Yoshimatsu S, Yamashita Y, et al.
Treatment of hepatocellular carcinoma: value of percutaneous microwave coagulation.
AJR Am J Roentgenol.
1995;
164
1159-1164
- 10
Ido K, Isoda N, Kawamoto C, et al.
Laparoscopic microwave coagulation therapy for solitary hepatocellular carcinoma performed
under laparoscopic ultrasonography.
Gastrointest Endosc.
1997;
45
415-420
- 11
Siperstein A E, Rogers A J, Hansen P D, et al.
Laparoscopic thermal ablation of hepatic neuroendocrine tumor metastases.
Surgery.
1997;
122
1147-1155
- 12
Cuschieri A, Brackaen J, Boni L.
Initial experience with laparoscopic ultrasound-guided radiofrequency thermal ablation
of hepatic tumors.
Endoscopy.
1999;
31
318-321
- 13
Couinaud C.
Les enveloppes vasculo-biliaires du foie ou capsule de Gilson.
Lyon Chirurg.
1954;
49
489-607
- 14
LeVeen R F.
Laser hyperthermia and radiofrequency ablation of hepatic lesions.
Semin lntervent Radiol.
1997;
14
313-324
- 15
Ohmoto K, Tsuzuki M, Yamamoto S.
Percutaneous microwave coagulation therapy with intraperitoneal saline infusion for
hepatocellular carcinoma in the hepatic dome.
AJR Am J Roentgenol.
1999;
172
65-66
- 16
Yamashita Y, Sakai T, Maekawa T, et al.
Thoracoscopic trans-diaphragmatic microwave coagulation therapy for a liver tumor.
Surg Endosc.
1998;
12
1254-1258
T. Ishikawa, M.D.
Dept. of Gastroenterology
University of Tokyo
7-3-1, Hongo, Bunkyo-ku
Tokyo, 113-8655
Japan
Fax: + 81-3-56843987
Email: takduck-tky@umin.ac.jp