Background and Study Aims: Though many gastric varices are treated endoscopically with n-butyl-2-cyanoacrylate,
its behavior in varices is not known precisely.
Materials and Methods: We created a varix model. A volume of 0.7 ml or 1.4 ml of 71.4 % n-butyl-2-cyanoacrylate,
a tissue adhesive, was injected into vinyl tubes of 0.4, 0.6, 0.9, and 1.2 cm in diameter,
which were filled with still blood or flowing blood. The tissue adhesive was also
injected into the inferior vena cava or femoral vein of dogs.
Results: N-butyl-2-cyanoacrylate was similarly polymerized in the vinyl tubes and the animal
veins. A volume of 0.7 ml of the tissue adhesive could block all tubes up to 0.6 cm
in diameter. A double quantity of the tissue adhesive could block tubes 0.9 and 1.2
cm in diameter, with flow velocities up to 10 cm/s and up to 5 cm/s, respectively.
Some polymer masses were fragmented.
Conclusions: One rapid shot of the tissue adhesive can block a vessel 0.6 cm or less in diameter
with fast flow velocity, and a vessel up to 1.2 cm in diameter with slow flow velocity.
Fast blood flows in a larger diameter vessel and slow injection of the tissue adhesive
may result in fragmentation. This model of the varix was useful for assessing the
effect of tissue adhesive used to treat gastric varices.
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T. Suga, M.D.
Second Dept. of Internal Medicine · Shinsu University School of Medicine
3-1-1 Asahi · Matsumoto-shi · Nagano, 390-8621 · Japan
Fax: + 81-263-329412
eMail: cqj04573@nifty.ne.jp
