1,2-Bis-N-[2′-(diphenylphosphino)-benzo/naphtho]-1,2-diamino-cyclo-hexane - Trost Modular Ligands

Introduction

Over the past ten years Trost et al. have developed a modular approach to ligand design for the Pd-catalysed asymmetric allylic alkylation (AAA) reaction. Much attention has focused on ligands such as 1a and its variant 1b which, under appropriate conditions, provide outstanding selectivity in a broad range of Pd-catalysed reactions. [1] [2] It should be noted that the mode of ligand bonding is not exclusively P,P-chelating, as in complexes 2a and 2b, and that ligand coordination is non-C₂-symmetric. [3] Applications and uses of 1a and 1b are described.

Figure

References

• 1 Trost BM. Van Vranken DL. Chem. Rev.  1996,  96:  395 
• 2 Trost BM. Van Vranken DL. Bingel C. J. Am. Chem. Soc.  1992,  114:  9327 
• 3 Fairlamb IJS. Lloyd-Jones GC. Chem. Commun.  2000,  2447 
• 4 Löber O. Kawatsura M. Hartwig JF. J. Am. Chem. Soc.  2001,  123:  4366 
• 5a Trost BM. Surivet J.-P. J. Am. Chem. Soc.  2000,  122:  6291 
• 5b Trost BM. Surivet J.-P. Angew. Chem. Int. Ed.  2000,  39:  3122 
• 6 Trost BM. Li L. Guile SD. J. Am. Chem. Soc.  1992,  114:  8745