Total synthesis of prelaureatin, which is an 8-membered cyclic
ether isolated from red alga Laurencia nipponica,
has been achieved through a process including stereoselective introduction
of two allyl groups starting from galactose pentaacetate, cleavage
of the hexose ring, and transformation of an acyclic triene into
an oxocene by selective ring-closing metathesis.
total synthesis - stereoselective synthesis - natural
products - ethers - metathesis
