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Semin Respir Crit Care Med 2002; 23(5): 449-456
DOI: 10.1055/s-2002-35716
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Evolution of Antimicrobial Resistance: Impact on Antibiotic Use

Didier Guillemot1 , Anne Claude Crémieux2 , Patrice Courvalin1
  • 1Unité des Agents Antibactériens-Centre National de Reference des Antibiotiques, Institut Pasteur, Paris, France
  • 2Hopital Bichat-Faculté de Médecine Bichat Claude Bernard, Paris, France
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Publication History

Publication Date:
25 November 2002 (online)

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ABSTRACT

During the past 50 years, the permanent increase in bacterial resistance to antibiotics has led to modifications in therapeutic recommendations. Despite evidence that antimicrobial exposure of human populations is the most important driving force for the continuous increase in bacterial resistance, the studies of the impact of bacterial resistance on antibiotic use have, during the past, focused on clinical efficacy of individual treatments rather than on collective control of resistance. There are current changes in this attitude, mainly in hospitals, probably because hospital prescribers have experienced the consequences of resistance on their patients. However, in the community such an awareness is not likely to develop in the near future. Therefore, there is a need for public health decision makers to become more involved in prevention of the impact of resistance in antibiotic use.

KEYWORDS

Antimicrobial resistance - antibiotic use - therapeutic decision - drug policy

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