Evolution of Antimicrobial Resistance: Impact on Antibiotic Use

Didier Guillemot; Anne Claude Crémieux; Patrice Courvalin

doi:10.1055/s-2002-35716

Seminars in Respiratory and Critical Care Medicine, Table of Contents

Semin Respir Crit Care Med 2002; 23(5): 449-456
DOI: 10.1055/s-2002-35716

Evolution of Antimicrobial Resistance: Impact on Antibiotic Use

Didier Guillemot¹ , Anne Claude Crémieux² , Patrice Courvalin¹

¹Unité des Agents Antibactériens-Centre National de Reference des Antibiotiques, Institut Pasteur, Paris, France
²Hopital Bichat-Faculté de Médecine Bichat Claude Bernard, Paris, France

Abstract

ABSTRACT

During the past 50 years, the permanent increase in bacterial resistance to antibiotics has led to modifications in therapeutic recommendations. Despite evidence that antimicrobial exposure of human populations is the most important driving force for the continuous increase in bacterial resistance, the studies of the impact of bacterial resistance on antibiotic use have, during the past, focused on clinical efficacy of individual treatments rather than on collective control of resistance. There are current changes in this attitude, mainly in hospitals, probably because hospital prescribers have experienced the consequences of resistance on their patients. However, in the community such an awareness is not likely to develop in the near future. Therefore, there is a need for public health decision makers to become more involved in prevention of the impact of resistance in antibiotic use.

KEYWORDS

Antimicrobial resistance - antibiotic use - therapeutic decision - drug policy

Full Text

References

REFERENCES

1 Bruning L M. Emerging infectious diseases: threats to the OR?. <~>Interview by Kimberly Howell. Todays Surg Nurse . 1996; 18 21-23
2 The cost of antibiotic resistance: effect of resistance among Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa on length of hospital stay. Infect Control Hosp Epidemiol 2002; 23 106-108
3 Carmeli Y, Troillet N, Karchmer A W, Samore M H. Health and economic outcomes of antibiotic resistance in Pseudomonas aeruginosa Arch Intern Med . 1999; 159 1127-1132
4 Phelps C E. Bug/drug resistance: sometimes less is more. Med Care . 1989; 27 194-203
5 Neu H C. The crisis in antibiotic resistance. Science . 1992; 257 1064-1073
6 Greenwood D. Preserving the miracle of antibiotics. Lancet . 1995; 345 1371
7 Lipsitch M. Measuring and interpreting associations between antibiotic use and penicillin resistance in Streptococcus pneumoniae Clin Infect Dis . 2001; 32 1044-1054
8 Quintiliani Jr R, Sahm D, Courvalin P. Mechanisms of resistance to antimicrobial agents. In: Murray PR, Jo Baron E, Pfaller MA, Tenover FC, Yolken RH, eds. Manual of Clinical Microbiology 7th ed. Washington, DC: American Society for Microbiology 1998: 1505-1525
9 Courvalin P, Trieu-Cuot P. Minimizing potential resistance: the molecular view. Clin Infect Dis . 2001; S138- S146
10 Courvalin P. Combinatorial approach of bacteria to antibiotic resistance. Res Microbiol . 1999; 150 367-373
11 Paulsen I T, Brown M H, Skurray R A. Proton-dependent multidrug efflux systems. FEMS Microbiol Rev . 1996; 60 575-608
12 Nikaido H. Multidrug efflux pumps of gram-negative bacteria. J Bacteriol . 1996; 178 5853-5859
13 Chiou C C, McEllistrem M C. Novel penicillin-, cephalosporin-, and macrolide-resistant clones of Streptococcus pneumoniae serotypes 23F and 19F in Taiwan which differ from international epidemic clones. J Clin Microbiol . 2001; 39 1144-1147
14 Rowe-Magnus D A, Mazel D. Resistance gene capture. Curr Opin Microbiol . 1999; 7 483-488
15 Hall R M. Mobile gene cassettes and integrons: moving antibiotic resistance genes in gram-negative bacteria. Ciba Foundation Symposium . 1997; 192-202
16 Arthur M, Reynolds P, Courvalin P. Glycopeptide resistance in enterococci. Trends Microbiol . 1996; 4 401-407
17 Leclercq R, Courvalin P. Bacterial resistance to macrolide, lincosamide and streptogramin antibiotics by target modification. Antimicrob Agents Chemother . 1991; 35 1267-1272
18 Hooper D C. Mechanisms of action of antimicrobials: focus on fluoroquinolones. Clin Infect Dis . 2001; S9-S15
19 Gonzales R D, Schreckenberger P C, Graham M B, Kelkar S, DenBesten K, Quinn J P. Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid. Lancet . 2001; 357 1179
20 Tsiodras S, Gold H S, Sakoulas G. Linezolid resistance in a clinical isolate of Staphylococcus aureus Lancet . 2001; 358 207-208
21 Oliver A, Canton R, Campo P, Baquero F, Blasquez J. High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection. Science . 2000; 288 1251-1253
22 Sougakoff W, Goussard S, Gerbaud G, Courvalin P. Plasmid-mediated resistance to third-generation cephalosporins caused by point-mutations in TEM-type penicillinase genes. Rev Infect Dis . 1988; 10 879-884
23 Bergogne-Bérézin E, Towner K J. Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features. Clin Microbiol Rev . 1996; 9 148-165
24 Magit A E, Stool S E. Clinical guideline development for otitis media: a report on methodology. Otolaryngol Head Neck Surg . 1993; 109 478-481
25 Managing otitis media with effusion in young children. American Academy of Pediatrics, The Otitis Media Guideline Panel. Pediatrics 1994 94: 766-773
26 Managing otitis media with effusion in young children. Otitis Media Guideline Panel. Am Fam Physician 1994; 50 1003-1010
27 Otitis media with effusion in young children: guideline overview. Agency for Health Care Policy and Research, Rockville, Maryland. J Natl Med Assoc 1994; 86 731-793
28 Goossens H, Sprenger M J. Community acquired infections and bacterial resistance. BMJ . 1998; 317 654-657
29 Lebel M H, McCracken Jr H G. Delayed cerebrospinal fluid sterilization and adverse outcome of bacterial meningitis in infants and children. Pediatrics . 1989; 83 161-167
30 Buckingham S C, McCullers J A, Lujan-Zilbermann J, Knapp K M, Orman K L, English B K. Pneumococcal meningitis in children: relationship of antibiotic resistance to clinical characteristics and outcomes. Pediatr Infect Dis J . 2001; 20 837-843
31 Auburtin M, Porcher R, Bruneel F. Pneumococcal meningitis in the intensive care unit: prognostic factors of clinical outcome in a series of 80 cases. Am J Respir Crit Care Med . 2002; 165 713-717
32 Guillemot D, Carbon C, Balkau B. Low dosage and long treatment duration of beta-lactam: risk factors for carriage of penicillin-resistant Streptococcus pneumoniae JAMA . 1998; 279 365-370
33 Tan T Q, Schutze G E, Mason Jr O E, Kaplan S L. Antibiotic therapy and acute outcome of meningitis due to Streptococcus pneumoniae considered intermediately susceptible to broad-spectrum cephalosporins. Antimicrob Agents Chemother . 1994; 38 918-923
34 Rockowitz J, Tunkel A R. Bacterial meningitis: practical guidelines for management. Drugs . 1995; 50 838-853
35 Kollef M H, Sherman G, Ward S, Fraser V J. Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest . 1999; 115 462-474
36 Kollef M H. Inadequate antimicrobial treatment: an important determinant of outcome for hospitalized patients. Clin Infect Dis . 2000; S131-S138
37 Montravers P, Gauzit R, Muller C, Marmuse J P, Fichelle A, Desmonts J M. Emergence of antibiotic-resistant bacteria in cases of peritonitis after intraabdominal surgery affects the efficacy of empirical antimicrobial therapy. Clin Infect Dis . 1996; 23 486-494
38 Hanssen A D, Osmon D R. Assessment of patient selection criteria for treatment of the infected hip arthroplasty. Clin Orthop . 2000; 91-100
39 Mekontso-Dessap A, Kirsch M, Brun-Buisson C, Loisance D. Poststernotomy mediastinitis due to Staphylococcus aureus: comparison of methicillin-resistant and methicillin-susceptible cases. Clin Infect Dis . 2001; 32 877-883
40 Hyatt J M, Schentag J J. Pharmacodynamic modeling of risk factors for ciprofloxacin resistance in Pseudomonas aeruginosa Infect Control Hosp Epidemiol . 2000; 21(suppl) S9-S11
41 Sullivan A. Effect of antimicrobial agents on the ecological balance of human flora. Lancet Infect Dis . 2001; 1 101-114
42 Patterson J E. Antibiotic utilization: is there an effect on antimicrobial resistance?. Chest . 2001; 119(suppl) S426-S430
43 Woodward R S, Medoff G, Smith M D, Gray III L J. Antibiotic cost savings from formulary restrictions and physician monitoring in a medical-school-affiliated hospital. Am J Med . 1987; 83 817-823
44 Rahal J J, Urban C, Horn D. Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella JAMA . 1998; 280 1233-1237
45 White Jr C A, Atmar R L, Wilson J, Cate T R, Stager C E, Greenberg S B. Effects of requiring prior authorization for selected antimicrobials: expenditures, susceptibilities, and clinical outcomes. Clin Infect Dis . 1997; 25 230-239
46 Richardson L P, Wiseman S W, Malani P N, Lyons M J, Kauffman C A. Effectiveness of a vancomycin restriction policy in changing the prescribing patterns of house staff. Microb Drug Resist . 2000; 6 327-330
47 Leverstein-van Hall A M, Fluit A C, Blok H E. Control of nosocomial multiresistant Enterobacteriaceae using a temporary restrictive antibiotic agent policy. Eur J Clin Microbiol Infect Dis . 2001; 20 785-791
48 Yates R R. New intervention strategies for reducing antibiotic resistance. Chest . 1999; 115(suppl) S24-S27
49 Patterson J E, Hardin T C, Kelly C A, Garcia R C, Jorgensen J H. Association of antibiotic utilization measures and control of multiple-drug resistance in Klebsiella pneumoniae Infect Control Hosp Epidemiol . 2000; 21 455-458
50 May A K, Melton S M, McGwin G, Cross J M, Moser S A, Rue L W. Reduction of vancomycin-resistant enterococcal infections by limitation of broad-spectrum cephalosporin use in a trauma and burn intensive care unit. Shock . 2000; 14 259-264
51 Bassetti M, Di Biagio A, Rebesco B, Amalfitano M E, Topal J, Bassetti D. The effect of formulary restriction in the use of antibiotics in an Italian hospital. Eur J Clin Pharmacol . 2001; 57 529-534
52 McGowan Jr E J. Do intensive hospital antibiotic control programs prevent the spread of antibiotic resistance?. Infect Control Hosp Epidemiol . 1994; 15 478-483
53 Durbin Jr A W, Lapidas B, Goldmann D A. Improved antibiotic usage following introduction of a novel prescription system. JAMA . 1981; 246 1796-1800
54 Kortas K, Segreti J, Donnelly A, Pierpaoli P, Trenholme G, Levin G. An anti-infective review and monitoring program. Pharmacol Ther . 1993; 291-296
55 Thuong M, Shortgen F, Zazempa V, Girou E, Soussy C J, Brun-Buisson C. Appropriate use of restricted antimicrobial agents in hospitals: the importance of empirical therapy and assisted re-evaluation. J Antimicrob Chemother . 2000; 46 501-508
56 Shlaes D M, Gerding D N, John Jr F J. Society for Healthcare Epidemiology of America and Infectious Diseases Society of America Joint Committee on the Prevention of Antimicrobial Resistance: guidelines for the prevention of antimicrobial resistance in hospitals. Infect Control Hosp Epidemiol . 1997; 18 275-291
57 Burke J P, Pestotnik S L. Antibiotic cycling: what goes around comes around. Curr Opin Infect Dis . 2000; 13 367-369
58 Kollef M H. Is there a role for antibiotic cycling in the intensive care unit?. Crit Care Med . 2001; 29 N135-142
59 Evans R S, Pestotnik S L, Burke J P, Gardner R M, Larsen R A, Classen D C. Reducing the duration of prophylactic antibiotic use through computer monitoring of surgical patients. DICP . 1990; 24 351-354
60 Labarca J. Antibiotic cycling tested in nosocomial infections. Lancet . 2000; 355 992
61 Evans R S, Burke J P, Classen D C. Computerized identification of patients at high risk for hospital-acquired infection. Am J Infect Control . 1992; 20 4-10
62 Evans R S, Pestotnik S L, Classen D C, Burke J P. Development of an automated antibiotic consultant. MD Comput . 1993; 10 17-22
63 Evans R S, Classen D C, Pestotnik S L, Lundsgaarde H P, Burke J P. Improving empiric antibiotic selection using computer decision support. Arch Intern Med . 1994; 154 878-884
64 Evans R S, Pestotnik S L. Applications of medical informatics in antibiotic therapy. Adv Exp Med Biol . 1994; 349 87-96
65 Evans R S, Classen D C, Pestotnik S L, Clemmer T P, Weaver L K, Burke J P. A decision support tool for antibiotic therapy. Proc Annu Symp Comput Appl Med Care . 1995; 651-655
66 Evans R S, Pestotnik S L, Classen D C. A computer-assisted management program for antibiotics and other antiinfective agents. N Engl J Med . 1998; 338 232-238
67 Hospital antibiotic control measures in UK. Working Party of the British Society for Antimicrobial Chemotherapy. J Antimicrob Chemother . 1994; 34 21-42
68 Shojania K G, Yokoe D, Platt R, Fiskio J, Ma'luf N, Bates D W. Reducing vancomycin use utilizing a computer guideline: results of a randomized controlled trial. J Am Med Inform Assoc . 1998; 5 554-562
69 Wester C, Durairaj L, Schwartz D, Husain S, Martinez E, Evans A. Antibiotic resistance who cares? Physician perceptions of antibiotic resistance among inpatients: its magnitude, causes, and potential solution [abstract 529]. In: Annual Meeting of the Infectious Diseases Society of America Philadelphia: Infectious Diseases Society of America 1999
70 Murthy R. Implementation of strategies to control antimicrobial resistance. Chest . 2001; 119(suppl) S405-S411
71 Thrasher C M, Stefl M E, Dorner F H. Antibiotic therapy intervention at a community hospital: opportunities for cost and quality improvements. Hosp Top . 1995; 73 12-15
72 Finkelstein J A, Metlay J P, Davis R L, Rifas-Shiman S L, Dowell S F, Platt R. Antimicrobial use in defined populations of infants and young children. Arch Pediatr Adolesc Med . 2000; 154 395-400
73 Guillemot D, Maison P, Carbon C. Trends in antimicrobial drug use in the community-France, 1981-1992. J Infect Dis . 1998; 177 492-497
74 Nyquist A C, Gonzales R, Steiner J F, Sande M A. Antibiotic prescribing for children with colds, upper respiratory tract infections, and bronchitis. JAMA . 1998; 279 875-877
75 Zwar N, Wolk J, Gordon J, Sanson-Fisher R, Kehoe L. Influencing antibiotic prescribing in general practice: a trial of prescriber feedback and management guidelines. Fam Pract . 1999; 16 495-500
76 Finkelstein J A, Davis R L, Dowell S F. Reducing antibiotic use in children: a randomized trial in 12 practices. Pediatrics . 2001; 108 1-7
77 Butler C C, Rollnick S, Kinnersley P, Jones A, Stott N. Reducing antibiotics for respiratory tract symptoms in primary care: consolidating ``why'' and considering ``how''. Br J Gen Pract . 1998; 48 1865-1870
78 Butler C C, Rollnick S, Pill R, Maggs-Rapport F, Stott N. Understanding the culture of prescribing: qualitative study of general practitioners' and patients' perceptions of antibiotics for sore throats. BMJ . 1998; 317 637-642
79 Monnet D L, Sorensen T L. The patient, their doctor, the regulator and the profit maker: conflicts and possible solutions. Clin Microbiol Infect . 2001; 7 27-30