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Endoscopy 2002; 34(12): 991-997
DOI: 10.1055/s-2002-35834
Original Article

© Georg Thieme Verlag Stuttgart · New York

Complications of Endoscopic Sphincterotomy: Results From a Single Tertiary Referral Center

M.  Barthet 1, 2 , N.  Lesavre 1, 2 , A.  Desjeux 1 , M.  Gasmi 1 , P.  Berthezene 2 , S.  Berdah 3 , X.  Viviand 1 , J.  C.  Grimaud 1
  • 1Department of Gastroenterology, Hôpital Nord, Marseille, France
  • 2Equipe mixte Inserm EMI, Marseille, France
  • 3Department of Surgery, Hôpital Nord, Marseille, France
Further Information

Publication History

Submitted: 27 January 2002

Accepted after Revision: 29 May 2002

Publication Date:
02 December 2002 (online)

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Background and Study Aims: Complications of endoscopic sphincterotomy (ES) have been assessed in recent multicenter studies. The aim of this series was to report and identify risk factors for complications of ES at a single tertiary referral center.
Patients and Methods: Between 1996 and 2000, 1159 consecutive endoscopic retrograde cholangiopancreatographies (ERCP) procedures were performed and their related complications were assessed. A total of 658 patients (57 %) underwent ES. All the clinical, radiological and biological data were carefully recorded within the 30 days following the procedure. Multivariate analysis was performed using a stepwise logistic model.
Results: The morbidity rate for ES was 7.7 %, being moderate to severe in 5 %. Morbidity included acute pancreatitis (3.5 %), perforations (1.8 %), sepsis (1.2 %) and bleeding (1.2 %). The 30-day mortality was 0.9 %. In the 1159 ERCP procedures, 231 patients underwent precut papillotomy (20 %) followed by sphincterotomy in 174 cases. Using logistic regression analysis, the risk factors for ES were precut papillotomy (relative risk, RR 2.76), confidence interval, (CI 1.39 - 5.49) and the presence of sphincter of Oddi dysfunction (RR, 7.72, CI 3.2 - 18.4).
Conclusions: In this single-center series, we found a complication rate of ES in about 7 %, comparable to that in multicenter series. Precut papillotomy and sphincter of Oddi dysfunction were the main independent risk factors for ES.

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M. Barthet, M.D.

Hôpital Nord

Chemin des Bourrelys · 13915 Marseille cedex 20 · France ·

Fax: + 33-4-91961311

Email: mbarthet@maiI.ap-hm.fr

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