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Sleep Breath 2003; 07(1): 003-012
DOI: 10.1055/s-2003-38947
Copyright © 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Nasal Continuous Positive Airway Pressure Improves Quality of Life in Obesity Hypoventilation Syndrome

Wataru Hida1,2 , Shinichi Okabe3 , Koichiro Tatsumi4 , Hiroshi Kimura5 , Tsuneto Akasiba6 , Kazuo Chin7 , Motoharu Ohi8 , Hideaki Nakayama9 , Makoto Satoh9 , Takayuki Kuriyama4
  • 1Health Administration Center, Tohoku University School of Medicine, Sendai
  • 2Department of Informatics on Pathophysiology, Tohoku University Graduate School of Information Sciences, Tohoku University School of Medicine, Sendai
  • 3First Department of Internal Medicine, Tohoku University School of Medicine, Sendai
  • 4Department of Respirology, Graduate School of Medicine, Chiba University, Chiba
  • 5Second Department of Internal Medicine, Nara Medical University, Nara
  • 6First Department of Internal Medicine, Nihon University School of Medicine, Tokyo
  • 7Division of Pulmonary Rehabilitation, Kyoto University School of Medicine, Kyoto
  • 8Osaka Kaisei Hospital, Osaka
  • 9Niigata University School of Medicine, Niigata, Japan
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Publication History

Publication Date:
24 April 2003 (online)

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ABSTRACT

We studied the quality of life of obesity hypoventilation syndrome (OHS) by comparing it with age- and body mass index-matched patients without hypoventilation and age-matched obstructive sleep apnea (OSA) patients with body mass index (BMI) under 30, and the efficacy of nasal continuous positive airway pressure (CPAP) therapy for 3 to 6 months on the quality of life in these patients. Prospectively recruited patients from six sleep laboratories in Japan were administered assessments of the general health status by the Short-Form 36 Health Survey (SF-36) and subjective sleepiness by the Epworth Sleepiness Scale (ESS). Compared with matched healthy subjects, OHS and OSA patients not yet treated had worse results on the ESS scores and the SF-36 subscales for physical functioning, role limitations due to physical problems, general health perception, energy/vitality, role limitations due to emotional problems, and social functioning. The ESS scores of OHS patients were worse than those of the OSA groups including the age- and BMI-matched OSA patients. In the SF-36 subscales of OHS patients, only the subscale of social functioning showed worse results compared with that of BMI-matched OSA patients. After 3 to 6 months of treatment, ESS scores and these SF-36 subscales in all three patient groups improved to the normal level. These results suggested that the quality of life of OHS before nasal CPAP was significantly impaired and that nasal CPAP for OHS improved the quality of life associated with the improvement of daytime sleepiness to the level of the other OSA patients.

KEYWORDS

Sleep apnea - hypercapnia - excessive daytime sleepiness

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