Efficient and Convergent Coupling Route for the Short-step Synthesis of Enantiopure 2α- and 2β-Alkylated 1α,25-Dihydroxy-19-norvitamin D₃ Analogues

Abstract

Novel efficient synthesis of several enantio-pure 2-alkyl­ated 1α,25-dihydroxy-19-norvitamin D₃ analogues through radical introduction of 2-alkyl chain and C₅-C₆ position coupling using Julia-type olefination as key steps was established starting from commercially available (-)-quinic acid as a chiral pool.

total synthesis - vitamin D - radical reactions - Julia reactions - coupling

References

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