Endoscopy 2003; 35(7): 559-563
DOI: 10.1055/s-2003-40240
Original Article
© Georg Thieme Verlag Stuttgart · New York

Value of Chromoendoscopy and Magnification Endoscopy in the Evaluation of Duodenal Abnormalities: a Prospective, Randomized Comparison

R.  Kiesslich 1 , K.  Mergener 2 , C.  Naumann 1 , M.  Hahn 3 , M.  Jung 4 , H.  H.  Koehler 5 , B.  Nafe 1 , S.  Kanzler 1 , P.  R.  Galle 1
  • 1 Dept. of Medicine I, Johannes Gutenberg University, Mainz, Germany
  • 2 Section of Gastroenterology, Virginia-Mason Medical Center, Seattle, Washington, USA
  • 3 Division of Gastroenterology, Beverly Hospital, Beverly, Massachusetts, USA
  • 4 Dept. of Internal Medicine, St. Hildegardis Hospital, Mainz, Germany
  • 5 Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
Further Information

Publication History

Submitted 8 August 2002

Accepted after Revision 25 February 2003

Publication Date:
24 June 2003 (online)

Background and Study Aims: Endoscopic staining methods are increasingly being used to evaluate lesions in the esophagus and colon. The aim of this prospective study was to investigate chromoendoscopy and magnification endoscopy for the evaluation of mucosal lesions in the duodenum.
Patients and Methods: Consecutive patients were randomly assigned to undergo conventional endoscopy without staining (group A) or intravital staining of the duodenal mucosa with indigo carmine and evaluation with a conventional video endoscope (group B) or a magnification endoscope (group C). Visible lesions were characterized before and after staining, and biopsies were taken for histological assessment.
Results: A total of 118 patients was examined. Chromoendoscopy detected significantly more lesions in the duodenal bulb (98 vs. 28; P = 0.0042) in more patients (29 vs. 15; P = 0.0025) compared with conventional endoscopy (group A). After mucosal staining, there was no difference between video endoscopy and magnification endoscopy with regard to the number or extent of the lesions identified. Significantly more targeted biopsies were possible after intravital staining. The most commonly identified lesions on targeted biopsies included (staining/control groups): gastric metaplasia (14/3), hyperplastic Brunner’s glands (6/3), inflammatory changes (7/6), villous atrophy (1/3), adenoma (1/0).
Conclusions: Intravital staining of the duodenum with indigo carmine may be useful for detecting mucosal abnormalities, delineating their extent, and allowing targeted biopsies. Magnification endoscopy, when used in addition to chromoendoscopy, does not appear to further increase the diagnostic yield for detecting duodenal abnormalities.


R. Kiesslich, M. D.

I. Med. Klinik und Poliklinik

Johannes-Gutenberg-Universität Mainz · Langenbeckstrasse 1 · 55101 Mainz · Germany

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