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Endoscopy 2003; 35(8): 675-678
DOI: 10.1055/s-2003-41517
Original Article

© Georg Thieme Verlag Stuttgart · New York

Use of Fibrin Glue (Beriplast) in the Management of Bleeding Gastric Varices

D.  Datta1 , P.  Vlavianos1 , A.  Alisa1 , D.  Westaby1
  • 1Dept. of Gastroenterology, Chelsea and Westminster Hospital, London, UK
Further Information

Publication History

Submitted 20 April 2003

Accepted after Revision 13 May 2003

Publication Date:
20 August 2003 (online)

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Background and Aims: Gastric variceal bleeding is a serious complication of portal hypertension. The optimum endoscopic treatment of bleeding gastric varices is yet to be defined. We evaluated the use of Beriplast, which is a solution of fibrinogen and thrombin, in controlling gastric variceal bleeding.
Patients and Methods: Fifteen patients presenting with gastric variceal bleeding were entered into an open trial of endoscopic gastric intravariceal injection treatment with Beriplast (fibrin sealant) and followed for up to 1 month after endoscopic treatment.
Results: There was failure to control bleeding in one patient. Four patients had rebleeding after the index bleed. All four were reinjected with Beriplast, and the bleeding was controlled in three. All patients were followed for 30 days, and the 30-day mortality following injection treatment was one. Fourteen patients were discharged from the hospital after the first episode of gastric variceal bleeding. None of the patients had injection-induced complications.
Conclusions: These results show that Beriplast is a safe and simple endoscopic treatment option and is very effective in controlling gastric variceal bleeding.

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D. Datta, M.D.

Dept. of Gastroenterology · Chelsea and Westminster Hospital

369 Fulham Road · London SW10 9NH · UK

Fax: +44-20-874-68100

Email: dattauk@yahoo.co.uk

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