Endoscopy 2004; 36(12): 1094-1098
DOI: 10.1055/s-2004-826040
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Narrow-Band Imaging in the Diagnosis of Colorectal Mucosal Lesions: A Pilot Study

H.  Machida1 , Y.  Sano1 , Y.  Hamamoto1 , M.  Muto1 , T.  Kozu2 , H.  Tajiri3 , S.  Yoshida1
  • 1 Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan
  • 2Division of Endoscopy, National Cancer Center Hospital, Tokyo, Japan
  • 3Department of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan
Further Information

Publication History

Submitted 16 May 2004

Accepted after Revision 28 July 2004

Publication Date:
01 December 2004 (online)

Background and Study Aims: A newly developed narrow-band imaging (NBI) technique, in which modified optical filters were used in the light source of a video endoscope system, was applied during colonoscopy in a clinical setting. This pilot study evaluated the clinical feasibility of the NBI system for evaluating colorectal lesions.
Patients and Methods: A total of 43 colorectal lesions in 34 patients were included in the study. The quality of visualization of colorectal lesions and the accuracy of differentiation between neoplastic and non-neoplastic lesions using the NBI system were evaluated in comparison with results from conventional colonoscopy and with chromoendoscopy.
Results: For pit pattern delineation, NBI was superior to conventional endoscopy (P < 0.001), but inferior to chromoendoscopy (P < 0.05). NBI achieved better visualization of the mucosal vascular network and of the hue of lesions than conventional endoscopy (P < 0.05). However there was no significant difference between NBI and chromoendoscopy in differentiating neoplastic from non-neoplastic lesions (both techniques had a sensitivity of 100 % and a specificity 75 %). This was better than the results of conventional colonoscopy (sensitivity 83 %, specificity 44 %; P < 0.05 for specificity).
Conclusions: These results suggest that in the examination of colonic lesions the NBI system provides imaging features additional to those of both conventional endoscopy and chromoendoscopy. For distinguishing neoplasms from non-neoplastic lesions, NBI was equivalent to chromoendoscopy.


Y. Sano, M. D.

Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East

6-5-1 Kashiwanoha · Kashiwa-city · Chiba 277-8577 · Japan

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Email: ysano@east.ncc.go.jp