Alternative Krebstherapien mittels physikalisch-chemischer Methoden

Zusammenfassung

Basierend auf bioelektrochemischer Apoptose oder photodynamischer Nekrose von Krebszellen in vitro [[2]] wird nun der heutige Stand von Tumorregressionen bei Tieren und Patienten mittels Photodynamie, Gleichstromelektrolyse, Elektropuls und magnetischer-elektromagnetischer Felder referiert.

Hiermit werden folgende letale Effekte wirksam: Photooxidation von Nukleinsäuren, Verminderung der Mitoserate, elektrolytische Zerstörung der Zellstruktur, Porierung der Zellmembran für beschleunigtes Eindiffundieren von Zytostatika, Apoptose-Induktion und Nekrose, Expressionshemmung des immunoreaktiven p53-Proteins. Unterstützend wirken Kombinationen mit Hyperthermie und Hyperglykämie (pH-Erniedrigung zwecks Membranlabilisierung).

Nachdem auf zellulärer Ebene alle diese Varianten bereits getestet worden sind, haben die meisten davon auch bei Tierversuchen zum Erfolg geführt, während Einsätze bei Patienten bisher nur auf die invasiven Methoden wie Photodynamie, Gleichstromelektrolyse und Elektropuls beschränkt waren. Demgegenüber haben Magnetfelder B > 5 mT wesentliche Vorteile (schmerzfreie Tiefenwirkung), jedoch bedarf es in Deutschland noch mehr Initiative, um optimale Amplituden- und Frequenzfenster zu ermitteln.

Abstract

Based on bioelectrochemical apoptosis or photodynamical necrosis of cancer cells in vitro [[2]] „the state of art” of regression of tumors in animals and patients by photodynamics, direct current-electrolysis, electro pulse and magnetic-electromagnetic fields will be reviewed.

During treatments by them the following effects occur: photo oxidation of nucleic acids, inhibition of mitosis, electrolytic degradation of cell structure, poration of cell membrane causing accelerated penetration of cytostatic drugs, induction of apoptosis and necrosis, inhibition of expression of the immunoreactive p53 protein. These processes are supported by combinations with hyperthermia and hyperglycemia (decrease of pH-value and hence labilization of membrane structure).

After testing all these variants on the cellular level in vitro most of them have been applied for treatments of tumors of animals. But the curing of patients has been restricted up to now to the application of invasive photodynamics, direct-current electrolysis and electro pulse. In contrast to these strong agents the soft, non-invasive magnetic fields B > 5 mT would have essential advantages (painfree deep-effects). However, it needs more initiative in Germany to determine for these methods the optimal „windows” of amplitude and frequency.

Schlüsselwörter

Photodynamie - Gleichstromelektrolyse - Elektropuls - pulsierende elektromagnetische Felder - PEMF - Hyperthermie - Krebszellen - Tiertumoren - Krebspatienten

Keywords

Photodynamics - direct-current electrolysis - electro pulse - PEMF - hyperthermia - cancer cells - tumors of animals - cancer-patients

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