CuI/N,N-Dimethylglycine-Catalyzed Cross-Coupling Reaction of Vinyl Halides with Phenols and its Application to the Assembly of Substituted Benzofurans

Abstract

CuI-catalyzed coupling reaction of vinyl halides and phenols occurs at 60-90 °C with N,N-dimethylglycine hydro­chloride as the additive, giving vinyl aryl ethers in good yields. The cross-coupling products formed from o-iodophenols and vinyl ­iodides are converted into substituted benzofurans via an intra­molecular Heck reaction.

Key words

cross-coupling - vinyl aryl ethers - vinyl halides - benzofuran

References

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