Abstract
The Mitsunobu reaction is an important tool in carbocyclic nucleoside chemistry for the direct coupling of alcohols with heterocyclic bases under mild conditions. Here, we report on the influence of the alcohol on the N1- vs. O2 -alkylation of N 3-benzoylthymine under Mitsunobu conditions. Moreover, a method for predicting the product ratio of the alkylation reaction will be introduced.
Key words
Mitsunobu reaction - carbocyclic nucleosides - regioselectivity - antiviral agents - medicinal chemistry
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