Medizinalpilze in der Onkologie

Zusammenfassung

Seit Jahrzehnten werden in In-vitro- und In-vivo-Studien die Antitumoreigenschaften von Medizinalpilzen wie Maitake, Coriolus versicolor, Ling Zhi oder Royal Sun Agaricus untersucht. In der vorliegenden Arbeit werden die Wirkmechanismen diskutiert und aktuelle Studienergebnisse aus dem Bereich der onkologischen Mykotherapie dargestellt. Die theoretischen Erörterungen werden durch eine Falldarstellung aus der naturheilkundlich orientierten Arztpraxis ergänzt.

Eine Analyse der Ergebnisse lässt es als sinnvoll erscheinen, Medizinalpilze als adjuvante Heilmittel für onkologische Patienten einzusetzen. Auch Patienten mit erhöhtem Krebsrisiko (etwa wegen bestehender Präkanzerosen) könnten von einer gezielten Mykotherapie profitieren.

Abstract

Since many decades, the antitumor characteristics of medicinal mushrooms like Maitake, Coriolus versicolor, Ling Zhi or Royal Sun Agaricus have been examined in in vitro and in vivo studies. In the present article, the modes of action are discussed and topical study results from the field of oncologic mycotherapy are presented. The theoretic discussions are complemented by a case report from a naturopathically oriented doctor's practice.

Based on an analysis of the results it seems to be sensible, to use medicinal mushrooms as adjuvant remedies for oncologic patients. Also patients with an increased cancer risk (e.g. because of existing precanceroses) can profit from a targeted mycotherapy.

Schlüsselwörter

Medizinalpilze - Mykotherapie - Ganoderma lucidum - Coriolus versicolor - Grifola frondosa - Lentinula edodes - Agaricus Blazei Murrill - onkologische Erkrankungen - Prävention

Keywords

Medicinal mushrooms - mycotherapy - Ganoderma lucidum - Coriolus versicolor - Grifola frondosa - Lentinula edodes - Agaricus Blazei Murrill - oncologic diseases - prevention

Literatur

• 01 Ahn W S, Kim D J, Chae G T, Lee J M. et al . Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murrill Kyowa, in gynecological cancer patients undergoing chemotherapy.  Int J Gynecol Cancer. 2004;  14 589-94
• 02 Aoyagi K, Koufuji K, Yano S, Miyagi M. et al . Gastric cancer with liver metastasis effectively treated by intra-hepatic arterial infusion. Gan to kagaku.  Cancer & Chemotherapy. 2004;  31 1678-81
• 03 Borchers A, Keen C L, Gershwin M E. Mushrooms, Tumors, an Immunity: An Update.  Exp Biol Med. 2004;  229 393-406
• 04 Fullerton S A, Samadi A A, Tortorelis D G, Choudhury M S. et al . Induction of apoptosis in human prostatic cancer cells with beta-glucan (Maitake mushroom polysaccharide).  Mol Urol. 2000;  4 7-13
• 05 Gao Y, Zhou S, Jiang W, Huang M. et al . Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients.  Immunol Invest. 2003;  32 201-15
• 06 Hara M, Hanaoka T, Kobayashi M, Otani T. et al. . Cruciferous Vegetables, Mushrooms, and Gastrointestinal Cancer Risks in a Multicenter, Hospital-Based Case-Control Study in Japan.  Nutrition and Cancer. 2003;  46 138-147
• 07 Hattori T S, Komatsu N, Hichijo S, Itoh K. Protein-bound polysaccharide K induced apoptosis of the human Burkitt lymphoma cell line, Namalwa.  Biomed Pharmacother. 2004;  58 226-30
• 08 Ho J C, Konerding M A, Gaumann A, Groth M. et al . Fungal polysaccharopeptide inhibits tumor angiogenesis and tumor growth in mice.  Life Sci. 2004;  75 1343-56
• 09 Hui K P, Sit W H, Wan J M. Induction of S phase cell arrest and caspase activation by polysaccharide peptide isolated from Coriolus versicolor enhanced the cell cycle dependent activity and apoptotic cell death of doxorubicin and etoposide, but not cytarabine in HL-60 cells.  Oncol Rep. 2005;  14 145-55
• 10 Inoue A, Kodama N, Hiroaki N. Effect of maitake (Grifora frondosa) D-Fraction on control of T lymph node Th-1/Th-2 proportion.  Biol Pharm Bull. 2002;  25 536-40
• 11 Ivankovic S, Hirsl N, Jakopovic I, Jurin M. The Influence of Medicinal Mushroom Preparations on Mouse Tumors.  Int J of Medicinal Mushrooms. 2004;  6 107-116
• 12 Kasai H, He L M, Kawamura M, Yang P T. et al . IL-12 Production Inducued by Agaricus blazei Fraction H (ABH) Involves Toll-like Receptor (TLR).  Evid Based Complement Alternat Med. 2004;  1 259-67
• 13 Kimura Y, Kido T, Takaku T, Sumiyoshi M. et al . Isolation of an anti-angiogenic substance from Agaricus blazei Murrill: its antitumor and antimetastatic actions.  Cancer Sci. 2004;  95 758-64
• 14 Kobayashi H, Yoshida R, Kanada Y, Fukuda Y. et al . Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murrill on spontaneous and peritoneal disseminated metastasis in mouse model.  J Cancer Res Clin Oncol. 2005;  131 527-38
• 15 Kodama N, Asakawa A, Inui A, Masuda Y. et al . Enhancement of cytotoxicity of NK cells by D-Fraction, a Polysaccharide from Grifola frondosa.  Oncol Rep. 2005;  13 497-502
• 16 Kodama N, Harada N, Nanba H. A polysaccharide, extract from Grifola frondosa, induces Th-1 dominant responses in carcinoma-bearing BALB/c mice.  Jpn J Pharmacol. 2002;  90 357-60
• 17 Kubo N, Myojin Y, Shimamoto F, Kahsimoto N. et al . Protective effects of a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia and Agaricus blazei murrill against X-irradiation in B6C3F1mice: Increased small intestinal crypt survival and prolongation of average time to animal death.  Int J Mol Med. 2005;  15 401-6
• 18 Kuroiwa Y, Nishikawa A, Imazawa T, Kanki K. et al . Lack of subchronic toxicity of an aqueous extract of Agaricus blazei Murrill in F344 rats.  Food Chem Toxicol. 2005;  43 1047-53
• 19 Lull C, Wichers H J, Savelkoul H F J. Antiinflammatory and Immunomodulating Properties of Fungal Metabolites.  Mediatros of Inflammation. 2005;  2 68-80
• 20 Mao X W, Green L M, Gridley D S. Evaluation of polysaccharopeptide effects against C6 glioma in combination with radiation.  Oncology. 2001;  61 243-53
• 21 Matsunaga K, Ohhara M, Oguchi Y, Iijima H. et al . Antimetastatic effect of PSK, a protein-bound polysaccharide, against the B16-BL6 mouse melanoma.  Invasion Metastasis. 1996;  16 27-38
• 22 Mukai M, Tokunaga N, Yasuda S, Mukohyama S. et al . Long term survival after immunochemotherapy for juvenile colon cancer with peritoneal dissemination: a case report.  Oncol Rep. 2000;  7 1343-7
• 23 Stanley G, Harvey K, Slivova V, Jiang J. et al . Ganoderma ludicum suppresses angiogenesis through the inhibition of secretion of VEGF an TGF-beta1 from prostate cancer cells.  Biochem Biophys Res Commun. 2005;  330 46-52
• 24 Sung S K, Kim M J, Lee D H, Choung S Y. et al . β-Glucan of Ganoderma lucidum (W.Cru.: Fr.) Lloyd (Aphyllophoroycetideae) Cooperatively Induces Tumor Necrosis Factor-α and Interleukin-6 with Lipopolysaccharide by Binding to Dectin-1.  Int J of Medicinal Mushrooms. 2005;  7 193-200
• 25 Szuki H, Yamamoto K, Hayashi S, Shindo H. et al . A Case of metastatic submandibular lymphnode treated successfully with palliative oral (5-FU + PSK) chemotherapy in the elderly. Gan to kagaku ryoho.  Cancer & Chemotherapy. 2005;  32 863-5
• 26 Takeda N, Nio Y, Ohmor H, Sato Y. et al . Direct antitumor activity of the protein-bound polysaccharide PSK on human digestive organ cancer cell lines.  J Jpn Soc Cancer Ther. 1997;  32 374-384
• 27 Wachtel-Galor S, Tomlinso B, Benzie I F F. Ganoderma lucidum (‚Lingzhi’), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study.  British Journal of Nutrition. 2004;  91 263-269
• 28 Wada T, Wakamatsu Y, Bannai K, Kato M. et al . Suppression mechanism of angiogenesis by PSK.  Ann Cancer Res Therapy. 2002;  10 93-105
• 29 Zhang H, Morisaki T, Matsunaga H, Sato N. et al . Protein-bound polysaccharide PSK inhibits tumor invasiveness by down-regulation of TGF-beta1 and MMPs.  Clin Exp Metastasis. 2000;  18 343-52
• 30 Zheng R, Jie S, Hanchuan D, Moucheng W. Characterization and immunomodulating activities of polysaccharide from Lentinus edodes.  Int Immunopharmacol. 2005;  5 811-20
• 31 Zhou S, Gao Y, Chan E. Clinical Trials for Medicinal Mushrooms: Experience with Ganoderma ludicum (W. Curt.: Fr.) Lloyd (Lingzhi Mushroom).  Int J of Medicinal Mushrooms. 2005;  7 111-17

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