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Semin Reprod Med 2006; 24(2): 071-077
DOI: 10.1055/s-2006-939565
DOI: 10.1055/s-2006-939565
Androgen Physiology
Further Information
Publication History
Publication Date:
24 April 2006 (online)
ABSTRACT
Androgen receptors are present in numerous tissues throughout the female body, and knowledge of the specific actions of androgens at different sites is increasing, along with the understanding of their contribution to various pathophysiological states. This article reviews the physiology of androgens (testosterone and dihydrotestosterone) and immediate androgen precursors (dehydroepiandrosterone [DHEA], dehydroepiandrosterone sulfate [DHEAS], and androstenedione), with specific reference to the androgen receptor, production and metabolism of C-19 steroids, circulating androgen concentrations, and androgen actions. In addition, the evidence for physiological modulation of androgens including circadian variation, cyclical variation, age, and natural menopause is reviewed.
KEYWORDS
Women - androgens - physiology - testosterone
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Dr. Sonia DavisonM.B.B.S. FRACP
Women's Health Program, Monash Medical School
Alfred Hospital, Commercial Road, Prahran, Victoria, 3181, Australia
Email: Sonia.Davison@med.monash.edu.au