Endoscopic diagnosis and treatment of upper gastrointestinal tumors

Introduction

The purpose of this article is to sum up the research on advanced endoscopic techniques used to diagnose and treat tumors of the upper gastrointestinal tract presented at this year’s Digestive Disease Week (DDW), held in Los Angeles. Twenty papers selected from 155 screened (Figure [1]) are discussed in detail, in sections devoted to the diagnosis of cancer and precancerous lesions [1] [2] [3] [4] [5] [6] [7] [8], endotherapy for early cancer and precancerous lesions [9] [10] [11] [12] [13] [14] [15] [16] [17] [18], and endotherapy for advanced cancer [19] [20]. This review does not cover research on the use of biomarkers for endoscopic diagnosis of Barrett’s dysplasia and cancer.

Figure 1 A total of 155 abstracts on endoscopic diagnosis and treatment of upper gastrointestinal tumors presented at Digestive Disease Week 2006, broken down by topic (EMR, endoscopic mucosal resection; ESD, endoscopic submucosal dissection).

References

• 1 Eberl T, Jechart G, Golczyk M. et al . Can endo-cytoscope system (ECS) predict histology in neoplastic lesions? [abstract].  Gastrointest Endosc. 2006;  63 AB90
• 2 Pohl H, Koch M, Khalifa A. et al . Evaluation of an endocytoscopy system in the surveillance of patients with Barrett esophagus [abstract].  Gastrointest Endosc. 2006;  63 AB239
• 3 Friedland S, Soetikno R, Liu J. et al . Novel fiberoptic confocal fluorescence microendoscope [abstract].  Gastroenterology. 2006;  130 A-309
• 4 Goetz M, Fottner C, Schirrmacher E. et al . In vivo molecular and subsurface imaging by confocal real time mini-microscopy [abstract].  Gastroenterology. 2006;  130 A-310
• 5 Wong K ee, Molckovsky A, Wang K. et al . Diagnostic accuracy of Raman spectroscopy for the classification of dysplastic lesions in Barrett’s esophagus [abstract].  Gastrointest Endosc. 2006;  63 AB90
• 6 Wolfsen H, Hemminger L L, Wallace M B. Detection of residual Barrett’s mucosa after photodynamic therapy (PDT) using high definition narrow band imaging (HD-NBI) [abstract].  Gastroenterology. 2006;  130 A310
• 7 Nonaka S, Saito Y, Gotoda T. et al . Narrow band imaging (NBI) system is promising device to detect superficial pharyngeal cancer at an early stage in patients with esophageal squamous sell carcinoma (SCC) [abstract].  Gastrointest Endosc. 2006;  63 AB250
• 8 Machida H, Higuchi K, Tabuchi M. et al . Usefulness of narrow band imaging for the diagnosis of early gastric cancer: a comparison study with conventional endoscopy [abstract].  Gastrointest Endosc. 2006;  63 AB244
• 9 Michida T, Nakamura T, Ueda T. et al . Expanded indication of endoscopic submucosal dissection (ESD) for early gastric cancer (GC) - clinical outcomes of a prospective study [abstract].  Gastrointest Endosc. 2006;  63 AB159
• 10 Toyonaga T, Nishino E, Hirooka T. Endoscopic submucosal dissection using new devices (flushknife) for gastric tumors [abstract].  Gastrointest Endosc. 2006;  63 AB233
• 11 Takenaka R, Kawahara Y, Okada H. et al . Factors associated with local recurrence and incomplete resection in endoscopic submucosal dissection for the treatment of early gastric cancers [abstract].  Gastrointest Endosc. 2006;  63 AB182
• 12 Nomoto M, Watanabe Y, Iwashige M. et al . IT-ESD is useful technique for the elderly patients with gastric cancer [abstract].  Gastrointest Endosc. 2006;  63 AB241
• 13 Lee J Y, Ye B D, Kim S G. et al . The efficacy of endoscopic submucosal dissection for early gastric neoplasms using insulated-tip diathermic knife [abstract].  Gastrointest Endosc. 2006;  63 AB182
• 14 Oyama T, Hotta K. Endoscopic submucosal dissection for early esophageal cancer [abstract].  Gastrointest Endosc. 2006;  63 AB84
• 15 Mizuta H, Kuratani Y, Onishi T. et al . Evaluation of the endoscopic submucosal dissection (ESD) method for gastric tumors [abstract].  Gastrointest Endosc. 2006;  63 AB240
• 16 Pech O, Behrens A, May A. et al . Curative endoscopic therapy for Barrett’s early cancer and high grade dysplasia: long-term results in 304 patients [abstract].  Gastrointest Endosc. 2006;  63 AB84
• 17 Peters F P, Brakenhoff L P, Curvers W L. et al . Endoscopic resection for early esophageal and gastric neoplasia in 140 patients [abstract].  Gastrointest Endosc. 2006;  63 AB141
• 18 Ganz R, Overholt G, Panjehpour M. et al . Treatment of Barrett’s esophagus and high-grade dysplasia using the HALO-360 ablation system: a multi-center experience [abstract].  Gastrointest Endosc. 2006;  63 AB124
• 19 Chang K J, Senzer N, Swisher S. et al . Multi-center clinical trial using endoscopy (END) and endoscopic ultrasound (EUS) guided fine needle injection (FNI) of anti-tumor agent (TNFerade) in patients with locally advanced esophageal cancer [abstract].  Gastrointest Endosc. 2006;  63 AB84
• 20 Verschuur E M, Kuipers E J, van Soest E M. et al . Large diameter stents in the esophagus are safe and associated with a lower risk of recurrent dysphagia than small diameter stents [abstract].  Gastrointest Endosc. 2006;  63 AB123
• 21 Wang T D. Confocal microscopy from the bench to the bedside.  Gastrointest Endosc. 2005;  62 696-697
• 22 Molckovsky A, Wong Kee Song L M, Shim M G. et al . Diagnostic potential of near-infrared Raman spectroscopy in the colon: differentiating adenomatous from hyperplastic polyps.  Gastrointest Endosc. 2003;  57 396-402
• 23 Aabakken L. Endoscopic tumor diagnosis and treatment.  Endoscopy. 2005;  37 1079-1083
• 24 Ganz R A, Utley D S, Stern R A. et al . Complete ablation of esophageal epithelium with a balloon-based bipolar electrode: a phased evaluation in the porcine and in the human esophagus.  Gastrointest Endosc. 2004;  60 1002-1010
• 25 Siersema P D, Hop W CJ, van Blankenstein M. et al . A new design metal stent (flamingo stent) for palliation of malignant dysphagia: a prospective study.  Gastrointest Endosc. 2000;  51 139-145