Endoscopy 2006; 38: 80-83
DOI: 10.1055/s-2006-946662
Invited papers
Mediastinal EUS
© Georg Thieme Verlag KG Stuttgart · New York

Competition for EUS (a) EBUS-TBNA (b) video assisted thoracoscopy

A. M. Lennon1 , R. C. Rintoul2 , I. D. Penman1
  • 1Western General Hospital, Edinburgh, UK
  • 2Papworth Hospital, Cambridge, UK
Further Information

Publication History

Publication Date:
26 June 2006 (online)

Introduction

Mediastinal lymph node enlargement occurs in up to 38 % of NSCLC at diagnosis [1]. The identification of cancer spread to the mediastinum, either as direct tumour invasion or as lymph node metastases, is critical as this not only determines prognosis but also treatment options. Stage I and II disease, where there is no evidence of spread outside the lung, is treated by surgical resection, while patients with low volume ipsilateral mediastinal lymph node metastases (stage IIIA) may be offered induction chemotherapy followed by resection. Chemotherapy/radiotherapy alone is reserved for patients with contralateral mediastinal or distant metastases (stage IIIB or IV).

References

  • 1 Dillemans B, Deneffe G, Vershakelen M. et al . Value of computed tomography and mediastinoscopy in preoperative evaulation of mediastional nodes in non-small cell lung cancer.  Eur J Cardiothorac Surg. 1994 ;  9 37-42
  • 2 Toloza E M, Harpole L, McCrory D C. et al . Noninvasive staging of non-small cell lung cancer: a review of the current evidence.  Chest. 2003;  123 137-146S
  • 3 Wallace M, Kennedy T, Durkalski V, Eloubeidi M A, Etamad R, Matsuda K. et al . Randomized controlled trial of EUS-guided fine needle aspiration techniques for the detection of malignant lymphadenopathy.  Gastrointest Endosc. 2001 ;  54 441-447
  • 4 Fritscher-Ravens A, Bohuslavizki K H, Brandt L, Bobrowski C. et al . Mediastinal lymph node involvement in potentialy resectable lung cancer: comparison of CT, positron emission tomography, and endoscopic ultrasound with and without fine-needle aspiration.  Chest. 2003;  123 442-451
  • 5 van Tinteren H, Hoekstra O S, Smit E F, van den Bergh J H. et al . Effectiveness of positron emission tomography in the preoperative assessment of patients with suspected non-small-cell lung cancer; the PLUS muticentre randomised trial.  Lancet. 2002;  359 1388-1393
  • 6 Viney R C, Boyer M J, King M T, Kenny P M. et al . Randomised controlled trial of the role of positron emission tomography in the management of stage I and II non-small-cell lung cancer.  J Clin Oncol. 2004;  22 2357-2362
  • 7 Herder G. Traditional versus up-front 18FDG PET staging of non-small cell lung cancer: a Dutch co-operative randomized study (abstract).  Proc Am Soc Clin Oncol. 2004;  23 615
  • 8 Schenk D A, Chambers S L, Derdak S, Komadina K H. et al . Comparison of the Wang 19-gauge and 22-gauge needles in the mediastinal staging of lung cancer.  Am Rev Respir Dis. 1993;  147 1251-1258
  • 9 Katis K, Inglesos E, Zachariadis E, Palamidas P. et al . The role of transbronchial needle aspiration in the diagnosis of peripheral lung masses or nodules.  Eur Respir J. 1995 ;  8 963-966
  • 10 Luke W P, Peason F G, Todd T R. et al . Prospective evaluation of mediastinoscopy for assessment of carcinoma of the lung.  J Thorac Cardiovasc Surg. 1986;  91 53-56
  • 11 Shields T W. Surgical treatment of non-small-cell bronchial carcinoma. in General thoracic surgery, S. TW, Editor. 1994 Williams and Wilkins New York; p. 1159-1169
  • 12 Fritscher-Ravens A, Soehendra N, Schirrow L, Parupudi V J. et al . Role of transoesophageal endosonography-guided fine-needle aspiration in the diagnosis of lung cancer.  Chest. 2000;  117 339-345
  • 13 Annema J, Vesleic M, Rabe K F. Analysis of subcarinal lymph nodes in suspected non-small-cell lung cancer after a negative transbronchial needle aspiration - what's next?.  Respiration. 2004;  71 630-634
  • 14 Caddy G, Conron M, Wright G, Desmond P. et al . The accuracy of EUS-FNA in assessing mediastinal lymphadenopathy and staging patients with NSCLC.  Eur Respir J. 2005 ;  25 410-415
  • 15 Caddy G CM, Wright G, Desmond P. et al . The accuracy of EUS-FNA in assessing mediastinal lymphadenopathy and staging patients with NSCLC.  Eur Respir J. 2005 ;  25 410-415
  • 16 Annema J T, V M, Veselic M, Voight P. et al . Endoscopic ultrasound-guided fine-needle aspiration in the diagnosis and staging of lung cancer and its impact on surgical staging.  J Clin Oncol. 2005;  23 8357-8361
  • 17 Wallace M B, Silvestri G A, Sahai A V, Hawes R H. et al . Endoscopic ultrasound-guided fine needle aspiration for staging patients with carcinoma of the lung.  Ann Thorac Surg. 2001;  72 1861-1867
  • 18 Frossard J L, Amouyal P, Amouyal G, Palazzo L. et al . Performance of endosonography-guided fine needle aspiration and biopsy in the diagnosis of pancreatic cystic lesions.  Am J Gastroenterol. 2003;  98 1516-1524
  • 19 Wallace M B, Ravenel J, Block M I, Fraig M. et al . Endoscopic ultrasound in lung cancer patients with a normal mediastinum on computed tomography.  Ann Thorac Surg. 2004;  77 1763-1768
  • 20 Eloubeidi M A, Cerfolio R J, Chen V K, Desmond R. et al . Endoscopic ultrasound-guided fine needle aspiration of mediastinal lymph node in patients with suspected lung cancer after positron emission tomography and computed tomography scans.  Ann Thorac Surg. 2005;  79 263-268
  • 21 Wiersema M J, Edell E S, Midthun D E. et al . Prospective comparison of transbronchial needle aspiration biopsy (TBNA) and endosonography-guided biopsy (EUS-FNA) of mediastinal lymph nodes in patients with know or suspected non-small cell lung cancer [abstract].  Gastroinest Endosc. 2002;  55 79
  • 22 Khoo K -L, Ho K -Y, Nilsson B, Lim T K. EUS-guided FNA immediately after unrevealing transbronchial needle aspiration in the evaluation of mediastinal lymphadenopathy: a prospective study.  Gastrintest Endosc. 2006 ;  63 215-220
  • 23 Larsen S S, Viemann P, Dirksen A, Clementsen P. et al . Endoscopic ultrasound guided biopsy versus mediastinoscopy for analysis of paratracheal and subcarinal lymph nodes in lung cancer staging.  Lung Cancer. 2005;  48 85-92
  • 24 Eloubeidi M A, Tamhane A, Chen V K, Cerfolio R J. Endoscopic ultrasound-guided fine-needle aspiration in patients with non small cell lung cancer and prior negative mediastinoscopy.  Ann Thorac Surg. 2005;  80 1231-1239
  • 25 Annema J, Versteegh M I, Veselic M, Welker L. et al . Endoscopic ultrasound added to mediastinoscopy for preoperative staging of patients with lung cancer.  Jama. 2005;  294 931-936
  • 26 Kramer H, van Putten J W, Post W J, van Dullemen H M. et al . Oesophageal endoscopic ultrasound with fine needle aspiration improves and simplifies the staging of lung cancer.  Thorax. 2004;  59 546-547
  • 27 Silvestri G A, Hoffman B J, Bhutani M S. et al . Endoscopic ultrasound with fine-needle aspiration in the diagnosis and staging of lung cancer.  Ann Thorac Surg. 1996;  61 1441-1446
  • 28 Rintoul R C, Skwarski K M, Murchison J T, Hill A. et al . Endoscopic and endobronchial ultrasound real-time fine-needle aspiration for staging of the mediastinum in lung cancer.  Chest. 2004;  126 2020-2022
  • 29 Krasnik M, Vilmann P, Larsen S S, Jacobsen G K. Preliminary experience with a new method of endoscopic transbronchial real time ultrasound guided biopsy for diagnosis of mediastinal and hilar lesions.  Thorax. 2003;  58 1083-1086
  • 30 Yasufuku K, Chiyo M, Sekine Y, Chhajed P N, Shibuya K, Iizasa T. et al . Real-time endobronchial ultrasound-guided transbronchial needle aspiration of mediastinal and hilar lymph nodes.  Chest. 2004;  126 122-128
  • 31 Rintoul R C, Skwarski K G, Murchison J T, Wallace W A. et al . Endobronchial and endoscopic ultrasound-guided real-time fine-needle aspiration for mediastinal staging.  Eur Respir J. 2005 ;  25 416-421
  • 32 Yasufuku K, C M, Koh E, Moriya Y. et al . Endobronchial ultrasound guided transbronchial needle aspiration for staging of lung cancer.  Lung Cancer. 2005;  50 347-354
  • 33 Vilmann P, Krasnik M, Larsen S S, Jacobsen G K. et al . Transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and endobronchial ultrasound-guided needle aspiration (EBUS-TBNA) biopsy: a combined approach in the evaluation of mediastinal lesions.  Endoscopy. 2005;  37 833-839
  • 34 Mentzer S J, Sugarbaker D J. Thoracoscopy and video-assisted thoracic surgery, in Current techniques in laparoscopy. D.C. Brooks, Editor 1994 Philadelphia; p. 1-20
  • 35 Roviaro G, Varoli F, Rebuffat C, Vergani C. et al . Videothoracoscopic staging and treatment of lung cancer.  Ann Thorac Surg. 1995;  59 971-974
  • 36 Sugarbaker D J, Strauss G M. Advances in surgical staging and therapy of non-small-cell lung cancer.  Semin Oncol. 1993;  20 163-72
  • 37 Walker W S. VATS lobectomy: the Edinburgh experience.  Semin Thorac Cardiovasc Surg. 1998;  10 291-299
  • 38 Loscertales J, Jimenez-Merchan R, Arenas-Linares C, Giron-Arjona J C. et al . The use of videoassisted thoracic surgery in lung cancer. Evaluation of resectability in 296 patients and 71 pulmonary exeresis with radical lymphadenoectomy.  Eur J Cardiothorac Surg. 1997 ;  12 892-897
  • 39 Fry W A, Siddiqui A, Pensler J M, Mostafavi H. Thoracoscopic implantation of cancer with a fatal outcome.  Ann Thorac Surg. 1995;  59 42-45
  • 40 Walsh F L, Nesbitt J C. Tumor implants after thoracoscopic resection of a metastatic sarcoma.  Ann Thorac Surg. 1995;  59 215-216

Dr. Ian D. Penman

Consultant Gastroenterologist

Western General Hospital

Edinburgh

EH4 2XU

UK

Phone: +44 131 537 1758

Fax: +44 131 537 1007

Email: ian.penman@luht.scot.nhs.uk

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