The acute and chronic effects of metoclopramide on aldosterone secretion in the rat
model were examined. Metoclopramide 50 μg iv in dexamethasone-treated rats did not
increase plasma aldosterone concentration. Chronic infusion of metoclopramide (72
μg/hr) over 5 days also did not show any increase in the plasma or urinary aldosterone
concentration when compared with control rats. Metoclopramide in vitro showed no effect
on aldosterone secretion from rat adrenal capsular cells but it inhibited serotonin-mediated
aldosterone secretion from the same cells significantly.
Aldosterone
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Catecholamines
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Dopamine
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Serotonin
