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Horm Metab Res 1986; 18(11): 754-756
DOI: 10.1055/s-2007-1012427
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© Georg Thieme Verlag, Stuttgart · New York

Metoclopramide Fails to Stimulate Aldosterone Secretion and Inhibits Serotonin-Mediated Aldosterone Secretion in the Rat

Tracy Hampton, A. Ganguly
  • James A. Haley Veterans Administration Hospital and University of South Florida College of Medicine, Tampa, Florida, U.S.A.
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Publication History

1985

1985

Publication Date:
14 March 2008 (online)

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Summary

The acute and chronic effects of metoclopramide on aldosterone secretion in the rat model were examined. Metoclopramide 50 μg iv in dexamethasone-treated rats did not increase plasma aldosterone concentration. Chronic infusion of metoclopramide (72 μg/hr) over 5 days also did not show any increase in the plasma or urinary aldosterone concentration when compared with control rats. Metoclopramide in vitro showed no effect on aldosterone secretion from rat adrenal capsular cells but it inhibited serotonin-mediated aldosterone secretion from the same cells significantly.

Key-Words

Aldosterone - Catecholamines - Dopamine - Serotonin

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