Serum C-peptide and insulin responses to oral glucose load were measured in 69 offspring
of conjugal diabetic parents (OCDP). The insulin responses were varied. The non obese
OCDP showed higher mean insulin levels than non obese controls while the obese OCDP
did not have significant differences in the mean insulin responses compared to obese
controls. The C-peptide levels were, however, low in both obese and non-obese OCDP.
The IRI/CP ratios were elevated in both groups of OCDP. These results suggest that
OCDP have low beta cell function and also possibly a change in the metabolism of insulin
at the hepatic level, which is more pronounced in non obese OCDP.
Offspring of Conjugal Diabetics
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C-Peptide
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IRI
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IRI/CP Ratio
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Beta Cell Function
