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Horm Metab Res 1984; 16: 142-144
DOI: 10.1055/s-2007-1014919
II. INSULIN SECRETION AND INSULIN ACTION
© Georg Thieme Verlag, Stuttgart · New York

Pancreatic Beta Cell Function in Offspring of Conjugal Diabetic Parents. Assessment by IRI and C-Peptide Ratio

C. Snehalatha, V. Mohan, A. Ramachandran, R. Jayashree, M. Viswanathan
  • Diabetes Research Centre and M.V. Hospital for Diabetes, Royapuram, Madras, India
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Publication History

1983

1983

Publication Date:
14 March 2008 (online)

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Summary

Serum C-peptide and insulin responses to oral glucose load were measured in 69 offspring of conjugal diabetic parents (OCDP). The insulin responses were varied. The non obese OCDP showed higher mean insulin levels than non obese controls while the obese OCDP did not have significant differences in the mean insulin responses compared to obese controls. The C-peptide levels were, however, low in both obese and non-obese OCDP. The IRI/CP ratios were elevated in both groups of OCDP. These results suggest that OCDP have low beta cell function and also possibly a change in the metabolism of insulin at the hepatic level, which is more pronounced in non obese OCDP.

Key-Words:

Offspring of Conjugal Diabetics - C-Peptide - IRI - IRI/CP Ratio - Beta Cell Function

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