Semin Reprod Med 1999; 17(3): 241-255
DOI: 10.1055/s-2007-1016232
Copyright © 1999 by Thieme Medical Publishers, Inc.

Progesterone-Regulated Gene Expression in the Primate Endometrium

William C. Okulicz, Christopher I. Ace
  • Departments of OB/GYN and Physiology, UMass Medical School, Worcester, Massachusetts.
Further Information

Publication History

Publication Date:
15 March 2008 (online)


Progesterone action is essential for maturation of the endometrium to a receptive state for implantation in humans and nonhuman primates. The orchestration of progesterone-regulated gene expression is also temporally controlled during the secretory phase based on the limited window for implantation. The genes and gene networks affected by progesterone are likely to involve both activation and repression. Our laboratory has used the rhesus monkey as a model to study the regulation of genes known or suspected to be involved in endometrial maturation. In addition, we have used subtractive hybridization and differential display techniques to identify novel or unsuspected genes that are regulated by progesterone during endometrial maturation. Our studies have led us to propose a working model of progesterone action during the primate secretory phase that includes waves of gene activation and repression that culminate in a receptive endometrium.