Endoscopy 1982; 14(1): 28-30
DOI: 10.1055/s-2007-1021569
© Georg Thieme Verlag KG Stuttgart · New York

Adenocarcinoma Occurring in a Hyperplastic (Metaplastic) Polyp of the Colon

G. Franzin, P. Novelli
  • Institute of Anatomical Pathology of the University of Padova, 37100 Verona, Italy
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Publication History

Publication Date:
17 March 2008 (online)


A case of adenocarcinoma occurring in a hyperplastic (metaplastic) polyp of the colon is presented. The polyp, two cm in diameter, was located in the transverse colon of a 45-year old male patient, and was removed endoscopically. From the periphery to the centre, the polyp showed epithelial changes progressing from hyperplastic to severely dysplastic, terminating in a central focus of invasive adenocarcinoma. It is suggested that the considerable number of absorptive cells in large hyperplastic polyps may occasionally result in an excessive absorption of carcinogen thus leading to dysplastic changes.