Endoscopy 2007; 39(9): 765-771
DOI: 10.1055/s-2007-966738
Original article

© Georg Thieme Verlag KG Stuttgart · New York

Endoscopic, bioptic, and manometric findings in eosinophilic esophagitis before and after steroid therapy: a case series

A.  J.  Lucendo1 , J.  M.  Pascual-Turrión1 , M.  Navarro2 , C.  Comas1 , P.  Castillo1 , A.  Letrán3 , M.  T.  Caballero3 , J.  Larrauri2
  • 1Department of Gastroenterology, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, Spain
  • 2Department of Pathology, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, Spain
  • 3Department of Allergy, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, Spain
Further Information

Publication History

submitted 24 August 2006

accepted after revision 14 June 2007

Publication Date:
17 August 2007 (online)

Background and aim: Eosinophilic esophagitis can be associated with a wide range of endoscopic patterns. The aim of the present case series report is to describe and classify endoscopic appearances before and after corticoid therapy in relation to histopathology and manometry.

Patients and methods: In 30 patients (m : f, 27 : 3; mean age 36.2 years) with eosinophilic esophagitis, endoscopic findings were prospectively classified according to luminal diameter and mucosal pattern. Manometric and bioptic histopathologic findings were also recorded. Endoscopy was repeated following a 3-month course of steroid therapy.

Results: In total, 20 % of patients showed a concentric esophageal stricture, and in 57 % simultaneous contraction rings were visible. Mucosal alterations consisted of granular mucosa (20 %), longitudinal furrows (33 %) and transversal undulations (3 %). Lower esophageal sphincter dysfunction and distal esophageal dysfunctional manometry were seen in 73 % and 57 % of cases, respectively. Following steroids, the esophagus showed a normal caliber in 97 % of patients, and 63 % of patients had normal mucosa.

Conclusions: The most frequent findings were narrowing of the esophageal lumen, which returned to normal following steroid treatment to a larger extent than mucosal alterations.

References

A. J. Lucendo, MD, PhD

Department of Gastroenterology, Hospital Universitario La Paz, Universidad Autónoma de Madrid

C/ Carnicer, 22, 3° B

28039 Madrid

Spain

Fax: +34-617-885975

Email: alucendo@vodafone.es