Capsule endoscopy

Introduction

Over the past 6 years or more, capsule endoscopy has emerged as a success story, not only in terms of its development for a variety of different indications and its use in different sites in the gastrointestinal tract, but also in that it has stimulated our thoughts on the optimal modern endoscopic work-up for each specific indication. This year at Digestive Disease Week there were around 77 abstracts concerned with capsule endoscopy. These included reports on the usefulness and safety of capsule endoscopy in different clinical situations, including obscure bleeding (for which capsule endoscopy now forms the basis of clinical management), Crohn’s disease, and the detection of small-bowel tumors (which can probably be regarded as a difficult application of capsule endoscopy); reports on topics specific to capsule endoscopy, such as the rationale for small-bowel preparation, the development of new capsules, technical (biochromoendoscopy) and software developments; and abstracts on the development of capsules designed specifically for different sites in the gastrointestinal tract (e. g. the Pillcam ESO in esophageal portal hypertension and the newer colon capsules). These numerous and interesting reports not only demonstrate the influence of capsule endoscopy on clinical management, but they also throw light on conventional endoscopy practices, including the rapid development of double-balloon enteroscopy, and the ongoing intense debate surrounding new methods for colonic neoplasia screening.

References

• 1 Levesque B, Sheibani S, Roost J, Gerso L B. Long-term impact of capsule endoscopy in patients with iron deficiency anemia.  Gastrointest Endosc. 2007;  65 AB91
• 2 Leung W K, Ho S S, Lau J Y. et al . Immediate capsule endoscopy or mesenteric angiogram in patients with acute overt obscure gastrointestinal bleeding: interim results of a prospective randomized trial.  Gastrointest Endosc. 2007;  65 AB128
• 3 Appalaneni V, Glenn T, Hoffman B J. Video capsule endoscopy: accuracy of Quick-view.  Gastrointest Endosc. 2007;  65 AB313
• 4 Kimble J S, Chak A, Isenberg G A. et al . Variation in diagnostic yield of back-to-back capsule endoscopy in obscure GI bleeding: final results.  Gastrointest Endosc. 2007;  65 AB185
• 5 Adler S A, Infantolino A, Costamania G. et al . Agile Patency System eliminates risk of capsule retention in patients with known intestinal strictures who undergo capsule endoscopy.  Gastrointest Endosc. 2007;  65 AB318
• 6 Cohen S A, Gralnek I M, Ephrath H. et al . Capsule endoscopy (CE) impacts diagnosis and alters management of pediatric inflammatory bowel disease (IBD): a prospective study.  Gastroenterology. 2007;  132 Suppl 2 A443
• 7 Voderholzer W A, Maiden L, Adler S N. et al . Interobserver variability of wireless capsule endoscopy (WCE) in patients with Crohn’s disease and NSAID enteropathy.  Gastroenterology. 2007;  132 Suppl 2 A190
• 8 Viazis N, Efthymiou A, Mantzaris G J. et al . Is clinical response followed by mucosal healing in patients with Crohn’s disease of the small bowel? A prospective multicenter study using wireless capsule endoscopy.  Gastroenterology. 2007;  132 Suppl 2 A172
• 9 Honda W, Ohmiya N, Arakawa D. et al . Diagnosis and treatment of small-intestinal tumors using double-balloon enteroscopy (DBE) and video capsule endoscopy (VCE).  Gastrointest Endosc. 2007;  65 AB186
• 10 Clarke J O, Giday S A, Magno P. et al . How good is capsule endoscopy for detection of periampullary lesions? Results of a tertiary referral center.  Gastroenterology. 2007;  132 Suppl 2 A358
• 11 Postgate A J, Fitzpatrick A, Bassett P, Fraser C H. Polyp detection and size estimation at capsule endoscopy: does experience improve accuracy? A prospective animal-model study.  Gastrointest Endosc. 2007;  65 AB316
• 12 Pasha S F, Leighton J A, Das A. et al . Double-balloon enteroscopy (DBE) and capsule endoscopy (CE) have a comparable diagnostic yield in patients with suspected small-bowel disease: a meta-analysis.  Gastrointest Endosc. 2007;  65 AB364
• 13 Tennyson C A, Lewis B S. Capsule endoscopy transit time and outcome of double-balloon enteroscopy.  Gastrointest Endosc. 2007;  65 AB167
• 14 Brotz C S, Nandi N, Schroeder T. et al . A validation study of 3 grading systems to evaluate small bowel cleansing for wireless capsule endoscopy (WCE): a quantitative index, qualitative evaluation, and overall adequacy assessment.  Gastroenterology. 2007;  132 Suppl 2 A500
• 15 De Franchis R, Eisen G M, Eliakim A R. et al . Esophageal capsule endoscopy (PillCam ESO) is comparable to traditional endoscopy for detection of esophageal varices: an international multi-center trial.  Gastrointest Endosc. 2007;  65 AB107
• 16 Bonino J A, Rastogi A, Wani S B. et al . Evaluation of esophageal capsule endoscopy (ECE) findings in gastroesophageal reflux disease and Barrett’s esophagus patients: are there differences between experienced gastroenterologists and trainees?.  Gastroenterology. 2007;  132 Suppl 2 A255
• 17 Coron E, Sacher-Huvelin S, Ben Soussan E. et al . Wireless esophageal capsule endoscopy (ECE): screening for esophagitis and Barrett’s esophagus (BE) in GERD and dyspepsia.  Gastrointest Endosc. 2007;  65 AB351
• 18 Delvaux M, Papanikolaou I S, Fassler I. et al . Oesophageal capsule endoscopy in patients with suspected oesophageal disease: double-blinded comparison with oesogastro-duodenoscopy and assessment of inter-observer variability.  Gastrointest Endosc. 2007;  65 AB155
• 19 Fritscher-Ravens A, Scherbakov P, Bufler P. et al . The feasibility of wireless capsule endoscopy in detecting small-intestinal pathology in young children less than age 8 years.  Gastrointest Endosc. 2007;  65 AB249
• 20 Schoofs N, Munoz Nava M, Fernandez-Urien I. et al . PillCam Colon capsule endoscopy compared to colonoscopy in detection of colon polyps and cancers: interim analysis of a prospective multi-center trial.  Gastroenterology. 2007;  132 2585-2586
• 21 Biancone L, Calabrese E, Petruzziello C. et al . Wireless capsule endoscopy versus small intestine contrast ultrasonography for assessing the postoperative recurrence of Crohn’s disease: a prospective longitudinal study.  Gastroenterology. 2007;  132 Suppl 2 A650
• 22 Dionisio P M, Leighton J A, Leontiadis G I. et al . Capsule endoscopy (CE) has a significantly higher diagnostic yield in patients with suspected and established non-stricturing Crohn’s disease (NSCD): a meta-analysis.  Gastrointest Endosc. 2007;  65 AB369
• 23 Efthymiou A, Viazis N, Mantzaris G J. et al . Is clinical response followed by mucosal healing in patients with Crohn’s disease of the small bowel? A prospective, multicenter study using wireless capsule endoscopy.  Gastroenterology. 2007;  132 Suppl 2 A172
• 24 Occhipinti P, Saettone S, Broglia L. et al . Safety of capsule endoscopy after Patency capsule in small bowel Crohn’s disease.  Gastrointest Endosc. 2007;  65 AB161
• 25 Singh M M, Saini S, Fisher L, Takami M. Negative serologic testing for Crohn’s disease is highly predictive of absence of small-intestinal inflammation on capsule endoscopy: results from a single academic center.  Gastroenterology. 2007;  132 Suppl 2 A157
• 26 Sugimori S, Watanabe T, Tabuchi M. et al . Evaluation of small-bowel injury in patients with rheumatoid arthritis by capsule endoscopy: effect of nonsteroidal anti-inflammatory drugs.  Gastrointest Endosc. 2007;  65 AB168
• 27 de Jonge P J, van Eijck B C, Geldof H. et al . PillCam ESO capsule endoscopy accurately detects abnormalities of the esophagus and is highly preferred by patients with symptomatic gastroesophageal reflux disease.  Gastroenterology. 2007;  132 Suppl 2 A284
• 28 Petre S A, Coulston J, Akins R. et al . Real-time viewing using string capsule endoscopy (SCE): preliminary experience in the esophagus.  Gastrointest Endosc. 2007;  65 AB341
• 29 Qureshi W A, Abudayyeh S, Wu J. et al . Capsule endoscopy for screening for short-segment Barrett’s esophagus.  Gastrointest Endosc. 2007;  65 AB131
• 30 Rodriguez-Luna H, Das A, Sharma V K, Ramirez F C. Cost-effectiveness of string capsule endoscopy for screening for Barrett’s esophagus.  Gastrointest Endosc. 2007;  65 AB364
• 31 Stipho S, Gilani N, Akins R. et al . The utility and safety of string capsule endoscopy (SCE) in patients with dysphagia.  Gastrointest Endosc. 2007;  65 AB138
• 32 Stipho S, Das A, Sharma V K, Ramirez F C. Cost-effectiveness of string capsule endoscopy for screening and surveillance of esophageal varices.  Gastrointest Endosc. 2007;  65 AB107
• 33 Wani S B, Rastogi A, Bonino J A. et al . Interobserver agreement for the detection of Barrett’s esophagus (BE) with esophageal capsule endoscopy (ECE).  Gastrointest Endosc. 2007;  65 AB138
• 34 Galter S, Gonzalez B, Villanueva C. et al . Sensitivity and specificity of the suspected blood identification system in capsule endoscopy.  Gastrointest Endosc. 2007;  65 AB174
• 35 Gonzalez B, Galter S, Villanueva C. et al . Rebleeding predictive factors in OGIB after capsule endoscopy: impact of double-balloon enteroscopy.  Gastrointest Endosc. 2007;  65 AB180
• 36 Hartmann D, Damian U, Eickhoff A, Riemann J F. Randomized study to diagnose small bowel pathology using paired capsule endoscopy with two different devices.  Gastrointest Endosc. 2007;  65 AB171
• 37 Intaraprasong P, Shah J, Law J. et al . A negative capsule endoscopy in the setting of obscure GI bleeding predicts a low-risk group for further bleeding whose resource utilization decreases post capsule study.  Gastrointest Endosc. 2007;  65 AB156
• 38 Jeen Y, Kim D, Keum B. et al . The different sensitivities of suspected blood indicator (SBI) system in capsule endoscopy according to differentiated potentially bleeding lesions.  Gastrointest Endosc. 2007;  65 AB177
• 39 Levesque B, Sheibani S, Roost J, Gerson L B. Long-term impact of capsule endoscopy in patients with iron deficiency anemia.  Gastrointest Endosc. 2007;  65 AB91
• 40 Pattullo V, Heap T R. Determination of the prevalence and classification of small intestinal angioectasias using video capsule endoscopy.  Gastrointest Endosc. 2007;  65 AB182
• 41 Ponferrada Diaz A, Gonzalez-Asanza C, Lozano Maya M. et al . Predictive factors of active bleeding lesions in capsule endoscopy studies.  Gastrointest Endosc. 2007;  65 AB166
• 42 Riccioni M E, Urgesi R, Spada C. et al . Unexplained iron deficiency anemia: is it worthwhile to perform capsule endoscopy?.  Gastrointest Endosc. 2007;  65 AB361
• 43 Alim S, Matin A, Man M, Kroser J. Factors affecting capsule endoscopy transit time.  Gastrointest Endosc. 2007;  65 AB344
• 44 Dunnigan M, Fenkel J M, Miller R R, Goldberg E M. Incomplete small-bowel examination during wireless capsule endoscopy is more common in inpatients.  Gastrointest Endosc. 2007;  65 AB165
• 45 Endo H, Matsuhashi N. Effects of concomitant polyethylene glycol ingestion during capsule endoscopy on the quality of image and completion rate to the cecum.  Gastrointest Endosc. 2007;  65 AB364
• 46 Galandauer I, Kalala S, Ross C. et al . Bowel prep for capsule endoscopy: predicting need using a novel approach for measuring study adequacy.  Gastrointest Endosc. 2007;  65 AB183
• 47 Karagiannis S, Dimopoulos F, Chrysanthopoulou H. et al . Comparison of two strategies for small-bowel preparation in capsule endoscopy.  Gastrointest Endosc. 2007;  65 AB315
• 48 Nandi N, Brotz C S, Schroeder T. et al . The standard preparation for wireless capsule endoscopy (WCE) is substandard.  Gastroenterology. 2007;  132 Suppl 2 A501
• 49 Pattullo V, Hansen R, Heap T R. Shortened duration video capsule endoscopy leads to significantly reduced rate of complete small bowel transit.  Gastrointest Endosc. 2007;  65 AB176
• 50 Pattullo V, Walsh A, Appleyard M N, Heap T R. The effect of right lateral posturing on gastric transit time and complete small-bowel transit in patients undergoing video capsule endoscopy.  Gastrointest Endosc. 2007;  65 AB165
• 51 Postgate A J, Fitzpatrick A, Patterson N, Fraser C. The role of bowel preparation and pro-kinetic agents in capsule endoscopy: a prospective randomized controlled trial.  Gastrointest Endosc. 2007;  65 AB318
• 52 Valenzuela G A, Fugman J. Tegaserod accelerates capsule endoscopy transit compared to metoclopramide.  Gastrointest Endosc. 2007;  65 AB331
• 53 Cheon J, Kim B, Kim Y. et al . Frequency and clinical outcomes of retention and factors predicting spontaneous delayed passage after retention during capsule endoscopy: a Korean nationwide multicenter study.  Gastrointest Endosc. 2007;  65 AB157
• 54 Higuchi K, Tabuchi M, Okazaki H. et al . Management of retention of capsule endoscopy: a-single-center experience where double-balloon enteroscopy is available.  Gastrointest Endosc. 2007;  65 AB168
• 55 Graepler F, Wolter M, Vonthein R, Gregor M. Accuracy of size estimation in wireless capsule endoscopy.  Gastrointest Endosc. 2007;  65 AB160
• 56 Honda W, Ohmiya N, Arakawa D. et al . Diagnosis and treatment of small-intestinal tumors using double-balloon enteroscopy (DBE) and video capsule endoscopy (VCE).  Gastrointest Endosc. 2007;  65 AB186
• 57 Rondonotti E, Pennazio M,. European Capsule Endoscopy Group . Small-bowel tumors detected by video capsule endoscopy (VCE): preliminary data from the ECEG (European Capsule Endoscopy Group) database.  Gastrointest Endosc. 2007;  65 AB90
• 58 Arakawa D, Ohmiya N, Nakamura M. et al . Diagnosis and treatment of obscure gastrointestinal bleeding (OGIB) at double-balloon endoscopy (DBE) in comparison with videocapsule endoscopy (VCE).  Gastrointest Endosc. 2007;  65 AB186
• 59 Higuchi K, Okazaki H, Tabuchi M. et al . Capsule endoscopy and double-balloon enteroscopy in the management of patients with portal hypertension and obscure gastrointestinal bleeding.  Gastrointest Endosc. 2007;  65 AB186
• 60 Kamalaporn P, Cho S, Basset N. et al . The comparative study of the detection rate between capsule endoscopy and double-balloon enteroscopy in our four-year experience.  Gastrointest Endosc. 2007;  65 AB170
• 61 Kim C, Kim Y, Kwon Y. et al . Efficacy of transit time method for localization of small-bowel lesions in capsule endoscopy.  Gastrointest Endosc. 2007;  65 AB177
• 62 Nakamura T, Oinuma T, Yamagishi H. et al . Comparison of capsule endoscopy and combination of capsule and double-balloon endoscopy in obscure gastrointestinal bleeding.  Gastrointest Endosc. 2007;  65 AB180
• 63 Tokar J L, Mustafa A, Nguyen M. et al . Correlation between double balloon endoscopy and capsule endoscopy in presumed small-bowel bleeding.  Gastrointest Endosc. 2007;  65 AB173
• 64 Ahmad N A, Joyce A. Clinical impact of capsule endoscopy on management of gastrointestinal disorders.  Gastrointest Endosc. 2007;  65 AB357
• 65 Benitez Roldan A, Caunedo-Alvarez A, Gomez-Rodriguez B J. et al . Effects of alendronate chronic consume on intestinal mucosa assessed by capsule endoscopy: a prospective controlled trial (preliminary data).  Gastrointest Endosc. 2007;  65 AB180
• 66 Fenkel J M, Goldberg E M, Grasso M A, Miller R R. Lymphangiectasia is more common in African-Americans by wireless capsule endoscopy.  Gastrointest Endosc. 2007;  65 AB182
• 67 Fylyk S N, Safatle-Ribeiro A V, Neves F. et al . Small intestine involvement in Behçet’s disease: a prospective, double-blind study comparing capsule endoscopy and double-balloon enteroscopy.  Gastrointest Endosc. 2007;  65 AB168
• 68 Isenberg G A, Kucera S, Wong R C, Chak A. Capsule endoscopy does not interfere with cardiac pacemaker function.  Gastroenterology. 2007;  132 Suppl 2 A498
• 69 Postgate A J, Fitzpatrick A, Fraser C. A prospective analysis of changes in performance indicators during a structured capsule endoscopy training programme.  Gastrointest Endosc. 2007;  65 AB331
• 70 Rey J, Alhassani A K, Lambert R. A two years experience with Olympus video capsule endoscopy (Endocapsule EC type 1).  Gastrointest Endosc. 2007;  65 AB335
• 71 Sanchez Yague A, Allen M, Cabral P. et al . Clinical utility of the RAPID Access RT for real-time viewing of capsule endoscopy.  Gastrointest Endosc. 2007;  65 AB356
• 72 Zhang H H, Scull B, Cecil G. et al . Biochromoendoscopy: capsule endoscopy with the cathepsin B activated molecular probe for imaging intestinal and gastric adenomas.  Gastrointest Endosc. 2007;  65 AB350
• 73 Mehendiratta V, DiMarino M, Infantolino A. et al . Capsule endoscopy in children: overall usefulness and special value in intestinal Crohn’s disease.  Gastrointest Endosc. 2007;  65 AB250
• 74 Moy L C, Levine J J. Clinical outcomes of pediatric Crohn’s disease diagnosed by capsule endoscopy.  Gastrointest Endosc. 2007;  65 AB250
• 75 Eswaran S, Rubin M, Green P H. Capsule endoscopy can make the diagnosis of celiac disease when duodenal biopsy fails.  Gastroenterology. 2007;  132 Suppl 2 A501
• 76 Eswaran S L, Rubin M, Green P H. The utility of capsule endoscopy in the management of celiac disease.  Gastroenterology. 2007;  132 Suppl 2 A664
• 77 Sigman T E, Costea F, Bernard C, Seidman E G. First case of refractory celiac disease and ulcerative jejunitis in a child revealed by capsule endoscopy.  Gastrointest Endosc. 2007;  65 AB250