Catalytic One-Pot, Three-Component Acyl-Strecker Reaction

Abstract

Different aldehydes and amines react with acyl cyanides in the presence of a catalytic amount of the Schreiner thiourea catalyst to give the corresponding N-acyl amino nitriles in high yields. The scope of the reaction is broad and both aromatic and aliphatic aldehydes and amines can readily be used.

acylcyanation - α-amino nitriles - multicomponent reactions - organocatalysis - acyl cyanides

References and Notes

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<A NAME="RG31706ST-10">10</A>

On mixing aldehyde, amine, catalyst, additive, and acetyl cyanide together at 0 °C, the product was obtained with poor yield due to considerable side product formation.