Semin Reprod Med 2007; 25(2): 093-098
DOI: 10.1055/s-2007-970048
Copyright © 2007 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Medical Therapy for Ectopic Pregnancy

Gary H. Lipscomb1
  • 1Professor and Associate Chairman for Clinical Affairs, Director Division of Gynecologic Services, Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, Tennessee
Further Information

Publication History

Publication Date:
22 March 2007 (online)


Methotrexate for treatment of ectopic tubal pregnancy has become an accepted alternative to surgical options. Methotrexate is a folic acid analog that interferes with DNA synthesis. Protocols using planned multiple doses of methotrexate alternating with citrovorum rescue factor and one protocol using only a single planned dose are both currently used in the treatment of ectopic pregnancy. In remains unclear which protocol is superior. This article reviews the indications, contraindications, and specifics of using methotrexate for this purpose. Also reviewed are predictors of success and management of usual complications associated with methotrexate therapy.


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Gary H LipscombM.D. 

Room E102, Department of Obstetrics and Gynecology, University of Tennessee Health Science Center

Memphis, TN 38163