Horm Metab Res 1996; 28(12): 633-637
DOI: 10.1055/s-2007-979868

© Georg Thieme Verlag Stuttgart · New York

Role of the β3-Adrenoceptor in the Control of Leptin Expression

J.-P. Gicaobino
  • Département de Biochimie Médicale, Centre Médical Universitaire, Genève, Switzerland
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Publication History



Publication Date:
23 April 2007 (online)


The inhibitory effect of β-adrenoceptor agonists on leptin expression in brown and white adipose tissues is now well documented both in vivo and in vitro. It suggests the existence in vivo of a retroregulatory loop by which leptin inhibits its own expression via the sympathetic nervous system and the β3-adrenoceptor. The hypothesis that the defect in β3-adrenoceptor described in the adipose tissue of hereditary obese rodents can contribute to the resistance to leptin and to the increase in leptin expression observed in these animals is discussed.