Horm Metab Res 1996; 28(12): 732-736
DOI: 10.1055/s-2007-979889
Originals Clinical

© Georg Thieme Verlag Stuttgart · New York

Plasma Leptin is Directly Related to Body Adiposity in Subjects with Spinal Cord Injury

W. A. Bauman1 , 2 , 3 , 5 , 6 , A. M. Spungen1 , 2 , 3 , Y.-G. Zhong1 , 2 , C. V. Mobbs4
  • 1The Spinal Cord Damage Research Center, Mount Sinai Medical Center, New York, NY
  • 2Departments of Medicine, Mount Sinai Medical Center, New York, NY
  • 3Rehabilitation Medicine, Mount Sinai Medical Center, New York, NY
  • 4Fishberg Center for Neurobiology and Geriatrics, Mount Sinai Medical Center, New York, NY
  • 5Spinal Cord Injury, Veterans Affairs Medical Center, Bronx, NY, U.S.A.
  • 6Medical Services, Veterans Affairs Medical Center, Bronx, NY, U.S.A.
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Publikationsverlauf

1996

1996

Publikationsdatum:
23. April 2007 (online)

Abstract

We addressed the relationship between plasma leptin and body mass index in 48 able-bodied male controls and 34 male subjects with spinal cord injury, as well as the association between plasma leptin with body fat by dual energy x-ray absorptiometry in those with spinal cord injury. In subjects with spinal cord injury, the effect of an oral glucose tolerance test and the relationship of the serum lipid profile with plasma leptin levels were determined. Body mass index was not significantly different between the spinal cord injury and control groups. Plasma leptin was significantly higher in the group with spinal cord injury than in the control group (12.7 ± 1.7 vs. 7.6 ± 0.9 ng/ml, p < 0.005). A linear relationship was found between plasma leptin and body mass index in both groups separately (spinal cord injury: r = 0.59, p < 0.0002; control: r 0.67, p < 0.0001). In those with SCI, a polynomial relationship was evident between plasma leptin and percent fat (r = 0.82, p < 0.0001). After an oral glucose load, plasma insulin levels and serum glucose concentrations were not related to plasma leptin levels. Serum triglycerides were found to be weakly correlated with plasma leptin levels (r = 0.35, p < 0.05). The higher plasma leptin levels in the group with spinal cord injury compared with the control group was probably due to a relatively increased percentage of adiposity in those with spinal cord injury.